Health Trials

Congenital Deafness

3

Review clinical trials related to Congenital Deafness. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 years of age.

Participants needed: 180
Trial details
Age: Up to 16Biological sex: AllType: ObservationalSponsor: SensorionUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Aged ≤ 16 years on the date of signed informed consent for cohort 1 and ≤ 10 yea... [+4]

Other type of deafness, such as unilateral deafness, persistent conductive deafn... [+2]

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Status: Recruiting

A Phase I/II Clinical Trial with SENS-501 in Children Suffering from Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations

This study intends to assess safety, tolerability, and efficacy of SENS-501 in children between the ages of 6-31 months with pre-lingual hearing loss due to a mutation in the Otoferlin gene.

Participants needed: 12
Trial details
Phase: Phase 1, Phase 2Age: 6-31Biological sex: AllType: InterventionalSponsor: SensorionUpdated: Sep 26, 2024Locations: 2
Eligibility criteria

Children (male or female) ≥ 6 to ≤ 31 months at the time of inclusion [+5]

History of chronic, acute, or major disease, or unspecified reasons, that in the... [+6]

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Status: Not yet recruiting

Genetic Feature of Congenital Hearing Loss in Chinese Population

Congenital hearing loss, as well as hearing loss present at birth, is one of the most common chronic conditions in children, with a prevalence of permanent bilateral hearing loss of 2.83 per 1000 children of primary school age, which is mainly caused by genetic factors. The goal of this observational study is to learn about novel causative genes in infants with hearing loss in the Chinese population. The main problem it aims to deal with are: * to present the genetic characteristics of the infant with hearing loss in the Chinese population * to build up a prognostic model base on diverse data. Participants will be asked to receive audiological tests and collection of the peripheral blood sample.

Participants needed: 50
Trial details
Age: Up to 6Biological sex: AllType: ObservationalSponsor: Dan BingUpdated: Apr 15, 2024
Eligibility criteria

Age up to 6 months [+3]

Congenital infections related to acquired or congenital hearing loss, including... [+3]

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