Health Trials

Elevated Lp(a)

2

Review clinical trials related to Elevated Lp(a). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Participants needed: 10,450
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Eli Lilly and CompanyUpdated: Jun 23, 2026Locations: 762
Eligibility criteria

Have Lp(a) ≥175 nanomoles per liter (nmol/L) [+5]

Have experienced a major cardiovascular event or surgery, such as heart attack,... [+6]

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Status: Not yet recruiting

2-HOBA Supplementation in People With Elevated Lipoprotein(a)

The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels. The main questions it aims to answer are: Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood? Participants will: Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers

Participants needed: 10
Trial details
Age: 18-69Biological sex: AllType: InterventionalSponsor: The Miriam HospitalUpdated: Sep 30, 2025Locations: 1
Eligibility criteria

Males and females aged 18-69 years. [+3]

Pregnant, planning pregnancy during the study period, or currently breastfeeding... [+10]

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