2-HOBA Supplementation in People With Elevated Lipoprotein(a)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-69
SponsorThe Miriam Hospital
About this trial
The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels.
The main questions it aims to answer are:
Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood?
Participants will:
Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers
Eligibility criteria
Qualifiers
Males and females aged 18-69 years.
Elevated Lp(a) levels ≥ 90 mg/dL.
Able to provide informed consent and adhere to study schedules.
Willing to follow a physician-recommended diet during the study.
Disqualifiers
Pregnant, planning pregnancy during the study period, or currently breastfeeding.
Individuals with established cardiovascular disease
Planning major changes in diet or exercise routines.
Experienced >20% weight change in the past 3 months.
Trial design
Treatments tested in this trial
- 2-HOBA (Hobamine)
Treatment groups
10 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov