Healthy Male and Female Subjects

The primary goal of this clinical trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules and riluzole tablets in the US healthy adult participants after single oral administration under fasted condition. The secondary goal of the trial is to evaluate the safety and tolerability of Y-4 tablets, pregabalin capsules and riluzole tablets in the US healthy adult participants.

This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of a patented age-reversal therapy, EGA®, compared to conventional nicotinamide mononucleotide (NMN) supplementation. The study will assess safety and efficacy in improving exercise tolerance and modulating biomarkers of aging in healthy older adults. The primary outcome is cycle ergometry constant work rate (CWR) exercise tolerance, measured as time to fatigue. Secondary outcomes include changes in peak oxygen consumption (VO₂peak), critical power, anaerobic work capacity, lactate threshold, and NAD⁺ metabolite levels. EGA® is composed of three metabolomic compounds that are endogenous to humans. The formulation has been used in prior exploratory studies and real-world applications, which have helped inform the design of this current trial.

This is a single-visit non-invasive study of healthy volunteer subjects. Brain activity will be measured with infra-red light sensors attached to a cap worn on the head, while both ears are gently stimulated with plastic filaments.

Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The objective is to assess the effect of food on the pharmacokinetics (PK) of pregabalin and riluzole in healthy adult subjects after a single oral dose of Y-4 tablets.

Background: Traditional Chinese Medicine (TCM) relies on pulse diagnosis, a subjective and complex method that is crucial for assessing patients' health status. The COVID-19 pandemic has disrupted healthcare delivery, highlighting the need for remote diagnostic tools. To address this, an Assistive Pulse Data Collection Device (APDC) has been developed to capture and regenerate pulse features for remote pulse assessment in TCM. Objective: This study aims to validate the accuracy and reliability of the APDC by assessing its agreement with Chinese Medicine Practitioners (CMPs) and collecting users' feedback. Intervention: The APDC consists of a radial artery viewing device, pulse collection device, and pulse regeneration device. Methods: Subjects will be recruited via social media and posters at the University. Inclusion criteria include age 18-65 years and BMI 18.5-22.5 kg/m2, while exclusion criteria include a dorsally located radial artery. Registered CMPs with at least 5 years of clinical experience will assess the pulse from both participants and the regenerated pulse by the device. Outcome Assessment: Agreement in pulse features between the subjects' real pulse and the pulse regeneration device will be assessed using a self-developed questionnaire, covering frequency, rhythm, wideness, and force. Quantitative and qualitative feedback from subjects and CMPs will be collected to assess their views on the APDC Device in terms of satisfaction, ease of use, and comfortability.

Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The objective of the trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules (Lyrica®) and riluzole tablets (Rilutek®) in Chinese healthy adult subjects after single oral administration under fasted condition.

The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating. The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating: 1. Whole-wheat bread and strawberry jam 2. Whole-wheat bread, strawberry jam, and avocado 3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado) Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.

Physical activity is essential for the healthy development of children, contributing significantly to their physical fitness and motor skills. Prepubertal children experience changes in physical growth. During the prepubertal phase, engaging in regular physical activity can lead to substantial improvements in cardiovascular health, muscular strength, agility, and coordination. Physical fitness has been recognized as a key determinant in healthy lifestyles based increasingly on criteria referenced to general health. However, many children and adolescents are only exposed to vigorous physical activity during school based physical education classes. That way, schools seem to provide an excellent setting to enhance physical activity and physical fitness levels. Soccer, a widely popular sport, offers an engaging and enjoyable way for children to improve their physical fitness and gross motor coordination. This study aims to investigate the effects of recreational soccer training on physical fitness and gross motor coordination in prepubertal boys and girls and to compare the effects of recreational soccer training between boys and girls. This current study will be a clinical trial; data will be calculated from Dar-e-Arqam School, upper mall Lahore. A total of 70 prepubertal children (35 boys and 35 girls) will be recruited for this study. Inclusion criteria for the study will be 7 to 9 years old boys and girls. participants should be in good general health, without any medical condition that could affect their ability to participate in physical activities. Individuals with physical disabilities or impairments that prevent them from engaging in soccer activities will be excluded. Participants will be divided into two experimental groups: Group A (boys) and Group B (girls). Both groups will undergo the same soccer training program. The soccer training program will consist of sessions held thrice a week for 8 weeks, each lasting 60 minutes.Outcomes to be analyzed will be Physical fitness and Gross motor coordination. Data collection will be done before and after the intervention. Tools used for data collection will be Physical fitness test battery for children to assess physical fitness and rohrer's index will be used to assess somatotype. Gross motor coordination will be evaluated using the Körperkoordinations test für Kinder (KTK) test battery. Data will be analyzed through SPSS version 26.00.

The goal of this clinical trial is to identify any differences in elbow ulnar collateral ligament (UCL) relative thickness and joint space laxity in the dominant arm following an 8-week course of low intensity resistance exercises with blood flow restriction (BFR) exercises in healthy volunteers. The main questions it aims to answer are: 1. Do BFR exercises contribute to a change in the relative ligament thickness of the UCL, and changes in the ulnohumeral joint space? 2. Are there changes in arm strength following the 8-week strengthening protocol with/without BFR? Participants will: * Complete two BFR sessions a week for a total of eight weeks. * Complete an exercise session with both arms (dominant arm will receive BFR) at each study visit. * Have sonographs taken of the UCL at the first and last study visit. * Complete strength assessments at the first and last study visit.