Labour Analgesia

5

Review clinical trials related to Labour Analgesia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia

Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors. The investigators hypothesized that relevant variables, able to predict the local anaesthetic (LA) requirement during labour, can be identified at admission and each parturient may therefore be accordingly classified in "low-requirement" and "high-requirement". In this way, a predictive score may be developed, and the analgesic regimen may be matched to the individual patient, thus ensuring a timely and appropriate treatment of patients likely to require higher doses of LA, while minimizing potentially side effects of excessive treatment in the low-dose group.

Participants needed: 12,500
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCSUpdated: May 29, 2026Locations: 1
Eligibility criteria

Parturients receiving neuraxial analgesia for labour, as clinical practice

Planned caesarean delivery

Status: Not yet recruiting

A Research Comparing Efficacy of PIEB Plus PCEA vs CEI Plus PCEA for Labour Analgesia

During labour process, one of the most effective ways to manage pain is via epidural analgesia. It is commonly and widely use for all pregnant women underwent labour process. It provides good pain relief during labour process especially for contraction pain and pain during descending of baby during delivery. During epidural insertion, a small catheter (which is flexible and thin) will be inserted via epidural needle at the back. Using this epidural catheter, pain medication will be given to ease and help controlling the pain. This procedure is usually done after you have been admitted to labour room. In this research, investigator will compare among two different method of epidural administration which are: \- Programmed Intermittent Epidural Bolus with Patient-Controlled Epidural Analgesia (PIEB + PCEA): * This method will enable the medication to be served automatically within the set time through the epidural catheter and allows for participants to manage additional boluses of medication according to the participants pain level. \- Continuous Epidural Infusion with Patient-Controlled Epidural Analgesia (CEI + PCEA): * This method will deliver continuous infusion of medication and allows for participants to manage additional boluses of medication according to the participants pain level. Investigator want to determine the best method between this two in order to have better pain control, less usage of medication and improving the satisfaction of patient. In participating this research, the participants will help us in understanding the best method to be use for the labour process in which eventually help other future patient who is in need.

Participants needed: 88
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Aiman Bin Ab AdzimUpdated: May 18, 2026Locations: 1
Eligibility criteria

All pregnant female > 36 weeks of gestation [+3]

Allergies to LA and opioids [+8]

Status: Not yet recruiting

A Digital Educational Resource to Improve Preparedness for Shared Decision Making About Labour Analgesia

Labour analgesia decisions are often made under time pressure, while in pain, which may lead patients to feel unprepared or uninformed. Shared decision-making (SDM) enhances patient satisfaction, promotes alignment with personal values, and improves trust in clinical care. Digital tools can support SDM by providing accessible, evidence-based information. The Society for Obstetric Anesthesia and Perinatology (SOAP) is an international organization made up of doctors who specialize in managing pain and anesthesia during pregnancy. Their focus is the wellbeing and safety of mothers and their babies from early pregnancy through delivery and recovery. The Painless Push digital resource educates mothers about ways to manage pain during labour. This trial aims to evaluate whether directing patients to access to the website https://thepainlesspush.com/ improves preparedness for shared decision-making compared to the current care, which is access to the Mount Sinai Obstetric Anesthesia website.

Participants needed: 200
Trial details
Age: 18-55Biological sex: FemaleType: InterventionalSponsor: Samuel Lunenfeld Research Institute, Mount Sinai HospitalUpdated: Apr 17, 2026Locations: 1
Eligibility criteria

Pregnant individuals ≥ 18 years [+4]

Sensory, cognitive, or language barriers precluding participation [+1]

Status: Not yet recruiting

Spinal Analgesia in Labour Pain

To evaluate the efficacy and safety of dexmedetomidine as an adjuvant to bupivacain and fentanyl in spinal Analgesia to decreases pain during normal labour

Participants needed: 100
Trial details
Phase: Phase 1Age: 18-40Biological sex: FemaleType: InterventionalSponsor: Minia University HospitalUpdated: Jan 12, 2026Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour

Epidural analgesia is the gold standard for painless labour, but successful catheter placement can be technically challenging due to anatomical and physiological changes in pregnancy. Injecting saline or local anesthetic through the epidural needle before catheter insertion has been proposed to facilitate catheter advancement by dilating the epidural space. This study aimed to evaluate the effect of epidural needle injection on the success rate and ease of catheter placement during labour analgesia.

Participants needed: 216
Trial details
Phase: Phase 3Age: 18-40Biological sex: FemaleType: InterventionalSponsor: Al-Azhar UniversityUpdated: Jan 8, 2026Locations: 1
Eligibility criteria

Female patients aged 18-40 years. [+7]

• Refusal to participate or to sign informed consent. [+14]