Mental Well-being

12

Review clinical trials related to Mental Well-being. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Strength for Caregiving

The goal of this single-arm pre-post study is to promote elderly (≥ 65 years) family caregivers' dietary habits, well-being and functional capacity through comprehensive nutritional guidance. The main goals of the project are to: * Improve the well-being, resilience, and functional capacity of the participating family caregivers through the comprehensive nutritional counseling implemented as part of the project. * Create a nutrition counseling model that promotes the well-being and coping of family caregivers and can also be utilized in well-being services counties after the project concludes. * Produce up-to-date and practical nutrition materials for family caregivers. The project participants will participate in two individual nutrition counselling sessions and three group nutrition counseling sessions over a period of ten months. Researchers will compare the results of the participants' baseline and final measurements to see if nutrition counseling is effective in improving family caregivers' well-being, resilience, and functional capacity.

Participants needed: 100
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: Susanna KunvikUpdated: Jun 8, 2026Locations: 1
Eligibility criteria

Born in 1961 or earlier (i.e. aged over 65 years) [+4]

Serious acute illness or inability to act as an informal caregiver [+3]

Status: Recruiting

Youth-for-Youth Mental Wellness Care and Action

This initiative aims to improve flourishing and quality of life of secondary school students, reduce mental distress (e.g., depression and suicidal ideation), enhance their understanding of mental health (e.g., mental health literacy) and help-seeking intention, and foster a supportive school environment (e.g., school climate-caring relationship, and sense of community). Also, this initiative aims to improve students' process of change in psychological (e.g., mattering, emotion regulation, empowerment) and social (e.g., trust belief) aspects and mental health awareness (e.g., mental health stigma). The feasibility, acceptability, and sustainability of the programme from multiple perspectives (e.g., students, student leaders, and stakeholders) will also be evaluated. In addition, the cost-effectiveness of delivering this programme (e.g., the incremental cost-effectiveness ratio (ICER)) among secondary schools in Hong Kong will be assessed. The programme will be implemented among students in 130 local secondary schools over three academic years. The first is a pilot phase (Year 1), which 40 schools will implement the intervention and student participants will be evaluated at pre- (T0) and post-intervention (T1) using questionnaires. In this stage, participatory research will be conducted before and after the intervention among students, student leaders, and stakeholders in 20 pilot schools to co-design the intervention, ensuring the programme meet the actual wellness needs of youth. In following two academic years, an additional 90 schools will participate in a cluster randomized controlled trial (RCT) with a 1:1 ratio between intervention and waitlist control groups. Each year, 45 schools will implement the intervention. Summative evaluation will be conducted among RCT schools at T0 and T1, and 3-month follow-up (T2). Quantitative data be collected to assess the effectiveness of intervention, and qualitative data will provide understanding of students' and stakeholders' perspectives of the intervention implementation. Cost outcomes will include intervention costs and cost savings, calculated from the payer (i.e., JC/government) perspective using administrative records or validated tools. The primary outcome of cost-effectiveness will be the quality-adjusted life-years (QALYs) of students. Cost of implementing the intervention program and QALYs will be used to evaluate the cost-effectiveness of the intervention, for example, estimate the incremental cost-effectiveness ratio (ICER).

Participants needed: 18,000
Trial details
Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: May 29, 2026Locations: 2
Eligibility criteria

student in Hong Kong secondary school [+4]

Not studying at Form 1 to 3 in Hong Kong secondary school [+3]

Status: Not yet recruiting

Creating Encounters Between Generations - Together Instead of Alone (GemsE)

Elderly people and children and young people (CYP) and from families with mentally ill parents are particularly affected by loneliness. The GemsE project is investigating whether intergenerational mentoring between seniors and children or young people helps to reduce loneliness and improve the mental well-being and quality of life of both groups. The aim of the study is to scientifically record the effect of these sponsorships and to find out how such encounters can be successfully organized.

Participants needed: 80
Trial details
Age: 12+Biological sex: AllType: InterventionalSponsor: Universitätsklinikum Hamburg-EppendorfUpdated: May 12, 2026
Eligibility criteria

Older adults aged 60 years and older who are residents of Hamburg [+3]

Children and adolescents with severe acute psychological symptoms requiring inpa... [+2]

Status: Not yet recruiting

Evaluating a Digital Intervention to Improve Resilience and Reduce Stress in Stanford Populations

High-achieving academic and entrepreneurial populations face elevated risks of chronic stress, anxiety, and burnout. These populations often underutilize mental health services due to stigma, time constraints, or accessibility issues. Digital interventions provide an opportunity to deliver evidence-based stress and resilience support at scale. The WONE (Walking on Earth, Ltd.) platform integrates personalized stress-resilience assessments, behavioral science micro-interventions, and optional wearable data feedback. This project aims to evaluate the feasibility, engagement, and preliminary efficacy of the WONE digital intervention in multiple Stanford-affiliated cohorts.

Participants needed: 260
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Stanford UniversityUpdated: May 4, 2026Locations: 1
Eligibility criteria

Aged between 18 and 65 years with Stanford affiliation [+6]

Psychiatric hospitalization for a mental health crisis in the past 12 months. [+2]

Status: Recruiting

Study of Self-Help and Support Services for Student Mental Health in Tertiary Institutions

This proposed study aims to evaluate the implementation of integrating the existing services in tertiary education institutions with the JCTH+ platform. The study aims to evaluate the efficacy of JCTH+ on students' mental health outcomes as compared to service as usual, and to assess the cost-utility of the platform to determine whether the benefits of implementing the platform justify the costs associated. It is hypothesized that participants who receive integrated self-help and support services will show (H1) a greater reduction in mental health symptoms, and (H2) better mental well-being compared with participants in the control condition, i.e. service-as-usual (SAU).

Participants needed: 1,684
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Mar 24, 2026Locations: 1
Eligibility criteria

18 years old or above [+4]

not able to read and understand Chinese; [+3]

Status: Recruiting

Randomized Controlled Trial on Precision Mental Health

The current study aims to evaluate the effectiveness of different online psychological interventions, including guided and unguided transdiagnostic cognitive behavioural therapy, and unguided mindfulness-based intervention, on mental well-being in comparison to waitlist control. It is hypothesized that participants with the guided psychological intervention will show (H1) a greater reduction in mental health symptoms, and (H2) better mental well-being compared with participants with unguided psychological intervention and the control condition.

Participants needed: 320
Trial details
Age: 17+Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Mar 25, 2026Locations: 1
Eligibility criteria

17 years old or above [+4]

People who are under 17 years old [+4]

Status: Not yet recruiting

Evaluation of the School-based SIM Program in Upper Secondary School Students

Söderqvist et al. recently reported on a new school-based program designed to promote mental well-being in adolescents: the Solution-Focused Intervention for Mental Health (SIM, https://doi.org/10.1016/j.ssmmh.2025.100493). While previous studies on SIM were designed mainly to test, develop, refine and improve the program and its feasibility in a school setting, the current project aims to test the efficacy of SIM on adolescent mental health, primarily mental well-being. A two-arm, cluster, randomized, controlled trial will be conducted. The intervention group will receive the SIM program, and the control group will receive a lecture on mental well-being along with the usual school provisions. Randomization is done by class because the intervention takes place in mentor groups. Based on the results of our largest feasibility study, 559 students are required for paired measurements to detect a small effect on mental well-being with 80% power and a significance level of 0.05. The evaluation is based on validated instruments, with measurements taken before and after the intervention, as well as six and nine months later. The project is being implemented in collaboration with six upper secondary schools in Sweden. Recruitment and anchoring at the participating schools, as well as class randomization strafied on educational program, took place in 2025. Enrollment of participating students will begin in January 2026. This project will contribute new knowledge to the field by evaluating a universal program for schools to use in their health promotion work. The latter is important since high levels of mental well-being independently predict a lower incidence of subsequent mental illness and have a range of positive effects on individuals and society.

Participants needed: 560
Trial details
Age: 15+Biological sex: AllType: InterventionalSponsor: Region Örebro CountyUpdated: Aug 8, 2025
Eligibility criteria

first and second-year upper secondary school students [+1]

students with insufficient knowledge of the Swedish language [+3]

Status: Recruiting

M3-JIA: Making Mindfulness Matter for Children With JIA

The investigator will evaluate the efficacy of M3©, an intervention for patients with JIA and their caregivers. Children with Juvenile arthritis and their parents will attend an 8 week online program called Making Mindfulness Matter (M3). This is a facilitator-led program that integrates knowledge and skills related to mindfulness, social-emotional learning, neuroscience, and positive psychology to promote coping and resiliency for children and families in context of the challenges of pediatric chronic disease. The child program is designed for children 4-12 years of age, with each lesson including a variety of concrete ways to teach children skills based on their age/developmental level.

Participants needed: 74
Trial details
Age: 4-12Biological sex: AllType: InterventionalSponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sUpdated: Jun 11, 2025Locations: 3
Eligibility criteria

Children aged 4 to 12 years diagnosed with JIA [+3]

Other major co-morbid disorders (e.g. Crohn's disease, diabetes, renal failure). [+1]

Status: Recruiting

Emotional Freedom Techniques and Virtual Reality Application for Fear of Childbirth

Fear of labour in primiparous pregnant women is an important factor that directly affects the mother-infant relationship and the mental health of the mother. In this process, it is common for expectant mothers to experience feelings of uncertainty and anxiety about labour. Such intense fear of birth may weaken maternal attachment and make it difficult for her to establish a healthy emotional relationship with her baby. In addition, this fear may negatively affect the mother's mental well-being and increase the risk of depression and anxiety. In this context, emotional liberation techniques (EFT) and virtual reality (VR) applications stand out as effective nonpharmacological methods used to reduce fear of childbirth in primiparous pregnant women. EFT is a technique that provides relaxation by touching the energy meridians that help the person to regulate negative emotions and cope with stress. SG, on the other hand, allows expectant mothers to interact with simulations similar to the real world in a virtual environment, providing therapeutic benefits through distraction, stress reduction and cognitive restructuring, allowing them to manage their fears about birth and enter the process more prepared. The use of SLT and SG, especially for primiparous pregnant women, can alleviate these women's anxiety about childbirth and enable them to approach the process in a safer and more conscious manner. Thus, it may also help to reduce the negative effects on the mother's postnatal attachment and mental health. This study aims to examine the effects of SLT and SG practices on fear of childbirth, attachment and mental well-being, and to reveal the effects of these two methods on primiparous pregnant women. In this context, this study will fill the gap in the literature by providing a new perspective in clinical practice and antenatal education programmes and will make important contributions to increase antenatal attachment and mental well-being in primiparous pregnancy.

Participants needed: 30
Trial details
Biological sex: FemaleType: InterventionalSponsor: Inonu UniversityUpdated: May 30, 2025Locations: 1
Eligibility criteria

No verbal communication problems [+6]

Not wanting to continue the research [+1]

Status: Recruiting

Youth Promotion of Resilience Involving Mental E-health

There is a critical gap in access to mental health promotion, prevention and support among youth worldwide, especially in low and middle-income countries like Vietnam. The Y-PRIME Study aims to respond to this gap by co-designing with Vietnamese youth a mobile app that delivers life skills and self-management skills intervention to promote mental well-being in grade 10 Vietnamese students. Working with the Vietnam Youth Advisory Council (V-YAC) to adapt and co-design the intervention and app ensure that the intervention will be culturally appropriate and relevant to Vietnamese youth. The goal of the current phase is to test this intervention with grade 10 students across three provinces (Hanoi, Thai Binh, and Hung Yen) to assess: 1. Whether the app helps to improve mental well-being and resilience among youth in Vietnam and helps to reduce factors that might increase the risk of poor mental well-being, like stress related to school and other pressures 2. Whether the app can be delivered in Vietnamese schools 3. Whether Vietnamese youth and school staff think the app is appropriate and appealing for youth in order to scale-up the model across the country The control group (meaning they do not have access to the app-based intervention) will complete the outcome survey at baseline, 6 months, and 12 months. After 12 months, they will gain access to the intervention app (at the same time as the experimental group) but no more data will be collected. The intervention group will use the app at their own pace for 1 year while completing the same survey at baseline, 6 months, and 12 months marks. Afterwards, students and school health staff will be invited to a focus group discussion to talk about their experience using the app.

Participants needed: 1,800
Trial details
Age: 15-16Biological sex: AllType: InterventionalSponsor: University of British ColumbiaUpdated: Mar 25, 2025Locations: 1
Eligibility criteria

Enrolled in grade 10 of participating secondary schools [+3]

Not in grade 10 [+4]

Status: Recruiting

PPI and Mindfulness App for Parents of Children with a NDD

An app based on positive psychology and mindfulness to support the mental well-being of parents of children with a Neurodevelopmental Disorder (NDD) was developed and will be evaluated on effectiveness.

Participants needed: 212
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of TwenteUpdated: Feb 21, 2025Locations: 1
Eligibility criteria

at least 18 years [+5]

presence of severe anxiety symptoms [+2]

Status: Recruiting

From the Heart: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults

The purpose of this study is to investigate and compare the effects of Christian and Islamic heart-centred spiritual meditation to mindfulness meditation and waitlist control conditions, respectively, in healthy adults. The potential effects will be studied at multiple levels, with a focus on psychophysiology, cognition, mental health, and social functioning.

Participants needed: 288
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Coventry UniversityUpdated: Aug 22, 2024Locations: 2
Eligibility criteria

18 to 60 years old [+3]

currently suffer from any mental health conditions or use medication to manage m... [+3]