Mixed Hemorrhoids

3

Review clinical trials related to Mixed Hemorrhoids. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Low Excision and High Suspension Hemorrhoidectomy Versus Conventional Milligan-Morgan Hemorrhoidectomy for Grade III-IV Mixed Hemorrhoids

Low Excision and High Suspension Hemorrhoidectomy versus Conventional Milligan-Morgan Hemorrhoidectomy for Mixed Hemorrhoids

Participants needed: 120
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: The Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineUpdated: Mar 27, 2026
Eligibility criteria

Diagnosed with Goligher grade III-IV mixed hemorrhoids via anorectal examination... [+2]

History of previous anorectal surgery; [+3]

Status: Not yet recruiting

HELO Trial: Energy-Based Therapies vs. Conventional Hemorrhoidectomy for Grade III Hemorrhoids

This prospective, multicenter study compares the efficacy and functional outcomes of three surgical treatments for symptomatic Goligher Grade III internal hemorrhoids: Laser Hemorrhoidoplasty (LHP), Hemorrhoid Energy Therapy (HET), and conventional closed hemorrhoidectomy (Ferguson technique). Due to strong patient preferences in hemorrhoidal surgery, this study utilizes a pragmatic, preference-tolerant design. Eligible patients will undergo standardized counseling and select their preferred treatment arm. The study aims to evaluate whether minimally invasive energy-based therapies offer superior postoperative pain relief and faster functional recovery compared to conventional hemorrhoidectomy

Participants needed: 60
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Chang Gung Memorial HospitalUpdated: Jan 12, 2026Locations: 1
Eligibility criteria

Diagnosed with Goligher Grade III internal hemorrhoids. [+5]

Other anorectal diseases (fistula, abscess, IBD, malignancy). [+3]

Status: Not yet recruiting

Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain.

Revised Translation (Academic English): As one of the most prevalent anorectal disorders, mixed hemorrhoids continue to rely on the Milligan-Morgan hemorrhoidectomy as the gold-standard surgical approach. While this technique demonstrates well-established efficacy, managing acute postoperative pain-particularly during the critical 24-72-hour peak pain window-remains a persistent clinical challenge. Recent advancements in multimodal analgesia have highlighted the potential of local nerve blockers, with methylene blue (MB) gaining scientific interest due to its prolonged analgesic properties. This randomized controlled study systematically evaluates the synergistic analgesic effects of gradient concentrations of MB combined with ropivacaine (ROP) following Milligan-Morgan procedures. Therapeutic safety profiles were validated through dual-dimensional monitoring of Visual Analog Scale (VAS) scores and complication rates, aiming to establish evidence-based optimal dosing protocols and refine perioperative pain management strategies.

Participants needed: 177
Trial details
Phase: Phase 4Age: 18-75Biological sex: AllType: InterventionalSponsor: The Affiliated Hospital of Putian UniversityUpdated: Sep 10, 2025Locations: 1
Eligibility criteria

Aged between 18 and 75 years. [+3]

Pregnancy or lactation. [+6]