Perforated Appendicitis

2

Review clinical trials related to Perforated Appendicitis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Perforated Appendicitis and Postoperative Antibiotics Pilot Trial

The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix. This pilot study will also help determine whether a larger, multi-centre study can be successfully conducted. The main questions it aims to answer are: * Do patients who do not receive antibiotics after surgery have similar rates of infection after surgery as patients who do? * Is it feasible to enroll and randomize patients and collect complete health data for a larger multi-centre study? Researchers will compare patients who do not receive antibiotics after surgery to patients who do to see whether avoiding antibiotics is as effective as using antibiotics for preventing infections after surgery. Participants will: * Be randomly assigned to either receive or not receive antibiotics after surgery for their perforated (burst) appendix. * Be contacted 30 and 90 days after surgery to check for infections and other health outcomes.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sUpdated: Jun 18, 2026
Eligibility criteria

Adults aged 18 years or older [+2]

Patients demonstrating signs of septic shock for whom the omission of systemic a... [+3]

Status: Recruiting

APPI-Cost Trial for Perforated Appendicitis

The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.

Participants needed: 346
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: The University of Texas Health Science Center, HoustonUpdated: Dec 11, 2025Locations: 1
Eligibility criteria

Plan to undergo appendectomy for acute appendicitis

Preoperative hemodynamic instability requiring ongoing infusion of vasopressors [+10]