Photophobia

5

Review clinical trials related to Photophobia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity

The purpose of this study is to gather pilot data on the effectiveness of daily disposable tinted contact lenses in reducing photophobia (light sensitivity) following a concussion, with the goal of facilitating the return to work or school.

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of Alabama at BirminghamUpdated: Jun 11, 2026Locations: 1
Eligibility criteria

diagnosed mild traumatic brain injury (concussion) [+3]

moderate or severe concussion [+2]

Status: Not yet recruiting

Comparison Between Spectacles and Contact Lenses

Many people suffer from migraine headaches, some more so than others and a common trigger/complaint is light sensitivity, or photophobia1. Some will go to great lengths to avoid light: a dark room with sunglasses on and blankets over the windows, often missing work/school/social activities, etc. Several ocular conditions are accompanied by photophobia, ranging from mild to debilitating.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of OklahomaUpdated: May 5, 2026Locations: 1
Eligibility criteria

Subjects must have worn FL-41 tinted spectacles for at least one month prior to... [+3]

Status: Recruiting

Light Exposure, Migraine Outcomes, and Sleep Quality

The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Arizona State UniversityUpdated: Apr 28, 2026Locations: 1
Eligibility criteria

Meet the International Classification of Headache Disorders, 3rd edition (2018)... [+4]

Light therapy [+2]

Status: Recruiting

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.

Participants needed: 36
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: VA Office of Research and DevelopmentUpdated: Dec 16, 2025Locations: 1
Eligibility criteria

Ages 18-65 [+3]

History of strabismus or amblyopia [+9]

Status: Recruiting

Objectively Diagnose and Monitor Treatment of Light Sensitivity

The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

Participants needed: 120
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Randy KardonUpdated: Nov 24, 2025Locations: 1
Eligibility criteria

Healthy individuals with normal eye exam in the previous year [+1]

History of eye or systemic disorder that affect the retina, optic nerve, visual... [+13]