Plaque, Dental

10

Review clinical trials related to Plaque, Dental. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival Bleeding

To assess the efficacy of a toothpaste containing chitosan in reducing plaque, gingivitis, and gingival bleeding, compared with Colgate Cavity Protection Toothpaste

Participants needed: 90
Trial details
Phase: Phase 3Age: 18-70Biological sex: AllType: InterventionalSponsor: Colgate PalmoliveUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Male or female, aged 18-70 years (inclusive). [+7]

Pregnant or lactating. [+14]

Status: Not yet recruiting

Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash

Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects. Aim of the study: Part I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated. Part II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.

Participants needed: 90
Trial details
Phase: Phase 2, Phase 3Age: 18-50Biological sex: AllType: InterventionalSponsor: Misr International UniversityUpdated: Jan 27, 2026
Eligibility criteria

Systemically free as reported by the patients [+4]

Patients with periodontitis or requiring other immediate dental treatments (with... [+8]

Status: Recruiting

Imaging-based Assessment of Oral Biofilm and Gingival Health

The purpose of this research study is to develop a better way of measuring the health of patients' mouth using photographs and imaging software. The investigators will also study the specific effects of individual toothpastes and mouthwashes on oral health. Participants who have volunteered to be in the study will be asked to use a toothpaste or over a period of 7 days to 6 months. The investigators will determine the participants' oral plaque levels, gum health, and saliva (spit) production with clinical exams as well as photographs of the participants' mouths. It is the hope of the study team to find better ways of assessing the health of patients' mouths and to identify whether gum health can be improved by specific toothpastes or mouthwashes.

Participants needed: 275
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of California, IrvineUpdated: Dec 23, 2025Locations: 1
Eligibility criteria

At least 18 years of age or older [+1]

History of allergy or intolerance of oral hygiene products such as toothpastes a...

Status: Recruiting

Novel Dental Gel as an Adjunct to Scaling and Root Planing

This study will evaluate the use of Livionex Dental Gel (LDG) as a home care product in reducing probing pocket depth (PD) beyond the effect achieved by the current standard of care with SRP in periodontitis patients.

Participants needed: 76
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: University of Alabama at BirminghamUpdated: Dec 17, 2025Locations: 1
Eligibility criteria

Male or female subjects at least 18 years of age. [+10]

• Pregnancy or breast feeding. [+15]

Status: Recruiting

Effectiveness of Plaque Score Detection Techniques

This study investigates the similarity between microbial plaque scores when assessing the entire dentition versus select teeth. The hypothesis posits that plaque buildup on single teeth mirrors that of the entire mouth, facilitating efficient plaque data collection and generalized deductions. Additionally, the research explores the potential of Dental Monitoring© photos in accurately identifying plaque indexes, aiming to enhance plaque evaluation efficiency in dental appointments. The null hypothesis suggests no significant difference between full dentition plaque scores and selected teeth. Results may streamline plaque tracking in patient appointments and enable remote monitoring, potentially detecting plaque accumulation issues earlier.

Participants needed: 50
Trial details
Age: 19-85Biological sex: AllType: ObservationalSponsor: University of NebraskaUpdated: Jun 11, 2025Locations: 1
Eligibility criteria

19-85 years old [+2]

No permanent dental devices (braces, splints) [+1]

Status: Recruiting

Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial

Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced dental skills. Introduced in the 1970s, the Hall technique offers a less invasive alternative, minimizing tooth reduction compared to SSCs. The SMART Hall technique represents a further evolution, emphasizing atraumatic cavity preparation using hand instruments. It offers advantages like minimal or no tooth reduction, minimized discomfort, improved patient cooperation, shorter treatment times, and cost-effectiveness. Silver Diamine Fluoride (SDF) emerges as a promising non-invasive approach for managing dental caries in primary teeth, though it may cause temporary tooth discoloration. However, comparative evaluation with traditional SSC restorations remains limited. To address this gap, a randomized clinical trial will evaluate the treatment outcomes of the SMART Hall technique versus conventional SSC restoration for managing occluso-proximal carious lesions (ICDAS CODE 3/4/5) in primary molars of young patients. Children aged 3 to 9 years requiring restorations will be included, assessing clinical outcomes, treatment time duration, and radiographical outcomes of both techniques at specific follow-up intervals of 3 months \& 6 months. This split mouth study will explore Clinical outcomes, radiographical outcomes, treatment time duration, and patient's pain perception with the chosen treatment modality. The findings will provide insights into the effectiveness and feasibility of the SMART Hall technique compared to the traditional SSC approach, informing evidence-based decision-making in pediatric dentistry and influencing treatment recommendations for preserving the health and function of primary molars in young children.

Participants needed: 30
Trial details
Age: 3-9Biological sex: AllType: InterventionalSponsor: C K S Teja Institute Of Dental Sciences & ResearchUpdated: Mar 3, 2025Locations: 1
Eligibility criteria

Children aged 3 to 9 years old. [+4]

Presence of severe systemic medical conditions (e.g., uncontrolled diabetes, imm... [+4]

Status: Recruiting

Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear Aligners

This study aimed to evaluate dental and periodontal health after interproximal enamel reduction and to compare Laser diode (a device used in the Orthodontic Program) and sodium fluoride (often used in the Orthodontic Program and in the Material Dental Program). The hypothesis was that the intervention groups would show a lower dentin hypersensitivity incidence than the control group during orthodontic treatment.

Participants needed: 30
Trial details
Age: 17-100Biological sex: AllType: InterventionalSponsor: University of Campania Luigi VanvitelliUpdated: Nov 14, 2024Locations: 1
Eligibility criteria

to be in orthodontic treatment with clear aligners and this treatment requires i... [+2]

enamel defects; [+4]

Status: Recruiting

Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt

Refugees, facing forced displacement and often exposed to traumatic experiences, represent a vulnerable population with unique healthcare needs. Oral health is considered a prominent factor that contributes to quality of life. Therefore, this study aim at assessing the effect of message framing on enhancing oral health practices in a group of refugees in Alexandria, Egypt. A three-arm cluster randomized controlled clinical trial will compare a gain-framed mobile text messages group, a loss-framed mobile text messages group, and a control group. The primary outcome is the improvement in oral health practices measured by changes in dental plaque and secondary outcome is to assess change in oral health-related quality of life. In addition, oral health knowledge, attitudes, and practices of refugees will be assessed.

Participants needed: 510
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Alexandria UniversityUpdated: Oct 21, 2024Locations: 1
Eligibility criteria

Refugees older than 18 years old. [+4]

Planning to move away during 1 year study period. [+1]

Status: Recruiting

Antibacterial Photodynamic Therapy in the Management of Peri-implantitis

This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term. In addition, the device might have a photobiomodulation effect on periodontal tissues, thus impacting osseointegration.

Participants needed: 80
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: Nilminie RathnayakeUpdated: Oct 18, 2024Locations: 1
Eligibility criteria

PPD ≥6 mm and marginal bone loss >3 mm [+3]

Presence of any physical limitation or restriction that might restrict Lumoral u... [+8]

Status: Recruiting

Analysis of the Effectiveness of the Use of Glycine Powder and Angled Implant Brush in Oral Hygiene Maintenance in Patients Reinstated With Columbus Bridge ProtocolTM

This study aims at comparing different procedures of Professional Oral Hygiene (POH) and Domiciliary Oral Hygiene (DOH) in Columbus Bridge ProtocolTM full-arch reinstated patients by dividing a sample of at least 74 patients into 4 groups with a 1:1:1:1 ratio. The patients will randomly be assigned to a "Standard" or "Glycine Perio Flow" Professional treatment, and to a "Standard" or "Angled" Toothbrush for their Domiciliary oral hygiene. Data about bacterial plaque presence is collected both before and after unscrewing the denture, when it comes to implant abutments. Instead, Denture Plaque Index will be collected after unscrewing the denture, by means of erythrosine and analyzed using a specific software that allows to compute the percentage of plaque on the denture. Patients will be seen after 3 months in order to figure out differences between DOH groups, by measuring plaque on abutments and on the denture after unscrewing it. At the moment there are no scientific studies trying to determine which professional and domiciliary procedures might be more efficient to control bacterial plaque in Columbus Bridge ProtocolTM reinstated patients. Statistically significant lower Plaque Index (PI) and Denture Plaque Index (DPI) scores are expected in patients treated with glycine perio flow, compared to standard treated patients. However, when it comes to angled toothbrush, lower PI and DPI are expected not to be statistically significant. Expectation from this study is to get information on how to improve full-arch patients' therapy in order to reduce peri-implant diseases which are related to bacterial plaque.

Participants needed: 74
Trial details
Biological sex: AllType: InterventionalSponsor: A.O.U. Città della Salute e della ScienzaUpdated: Jul 23, 2024Locations: 1
Eligibility criteria

Age >= 18years [+2]

Heavy smokers (>= 10 cigarettes per day) [+10]