Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
Trial statusNot yet recruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18-50
SponsorMisr International University
About this trial
Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects.
Aim of the study:
Part I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated.
Part II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.
Eligibility criteria
Qualifiers
Systemically free as reported by the patients
Minimum of 20 teeth present in the dentition (excluding wisdom teeth);
Clinically healthy gingiva (on intact periodontium)
Dental biofilm-induced gingivitis (plaque induced gingivitis) according to the criteria set by the American Academy of Periodontology for classification of periodontal diseases and conditions in 2017
Disqualifiers
Patients with periodontitis or requiring other immediate dental treatments (within the current 6 months)
Subjects on antibiotics within last 6 months
Periodontal therapy for the past 6 months
Pregnant women and lactating mothers
Trial design
Treatments tested in this trial
- Moringa Oleifera
- Chlorhexidine mouthwash
- Base formula
Treatment groups
90 Participants
are divided into 3 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov