Pneumoperitoneum

9

Review clinical trials related to Pneumoperitoneum. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Pneumoperitoneum Pressure and Lung Ultrasound Atelectasis

Elective laparoscopic cholecystectomy may lead to perioperative atelectasis due to pneumoperitoneum-related diaphragmatic elevation and impaired respiratory mechanics. Lung ultrasound (LUS) provides a noninvasive bedside method for evaluating perioperative aeration loss. This prospective randomized controlled study aims to compare the effects of low-pressure (10 mmHg) and standard-pressure (14 mmHg) pneumoperitoneum on perioperative atelectasis assessed by LUS in patients undergoing laparoscopic cholecystectomy under general anesthesia. Changes in LUS scores, respiratory mechanics, oxygenation, and postoperative clinical outcomes will also be evaluated.

Participants needed: 112
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Engin ÇetinUpdated: Jun 23, 2026Locations: 1
Eligibility criteria

Patients aged between 18 and 65 years [+4]

Chronic pulmonary disease [+9]

Status: Not yet recruiting

Maneuvers to Reduce Laparoscopic Pain

Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization. There is literature that demonstrates higher insufflation pressures being associated with increased postoperative pain - particularly shoulder pain - and opioid use. The ideal amount of intraperitoneal pressure is still under debate as other studies demonstrate that reduced pneumoperitoneum insufflation has also shown to negatively impact surgeon satisfaction and trended with longer operative time and greater blood loss without impacting pain. Residual intraperitoneal carbon dioxide can also contribute to postoperative discomfort. Studies have shown the effectiveness of various maneuvers in removing residual gas to reduce postoperative pain, such as intraperitoneal saline instillation, pulmonary recruitment, and gas aspiration via smoke evacuator. Despite these advantages, there is a lack of a clear consensus on the optimal method for reducing residual intraperitoneal gas. Conversely, literature has mixed results regarding the true significance in pain reduction. Given the importance of minimizing postoperative pain, reducing opioid requirements, and shortening postoperative recovery time, the investigators propose a prospective, patient-blinded, randomized controlled trial. The investigators aim to investigate whether active gas removal via a smoke evacuator, multiple breath recruitment maneuvers, or no intervention would contribute to lowest postoperative pain. The findings will help identify the most effective method for reducing residual pneumoperitoneum-related pain and thus inform surgical practices and improve patient outcomes.

Participants needed: 150
Trial details
Age: 18-65Biological sex: FemaleType: InterventionalSponsor: Henry Ford Health SystemUpdated: Jun 9, 2026Locations: 1
Eligibility criteria

Patients age 18 to 65 [+1]

Ages <18 and age >65 [+6]

Status: Not yet recruiting

Does Trendelenburg Positioning During Pulmonary Recruitment Breaths Affect Post-laparoscopy Shoulder Pain

The goal of this clinical trial is to evaluate whether different positioning in the operating room during removal of laparoscopic surgical gas differs in post-surgery shoulder pain. An additional goal of this study is to evaluate whether positions change other post-surgery metrics such as bloating, time to passing gas, nausea and vomiting, and time to oral intake. Researchers will compare Trendelenburg positioning where your head is tilted down to supine (level or flat) positioning during removal of surgical gas. Participants will be asked to complete brief surveys at 24 and 72-hours post-surgery.

Participants needed: 120
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Ankita GuptaUpdated: Jun 8, 2026
Eligibility criteria

Robot-assisted laparoscopic surgery for benign gynecologic indication [+2]

Patients with baseline opioid use [+5]

Status: Not yet recruiting

Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery

The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy. Laparoscopic surgery is performed in several stages, one of which involves the creation of a peritoneal detachment. This detachment is achieved by the addition of a gas (CO2), which requires total relaxation of the abdominal muscle fibers. To achieve this, it is advisable to administer a muscle relaxant called curare (2). Curare-induced neuromuscular block, its depth and its release must be monitored during surgery. Curares act as acetylcholine antagonists, inducing neuromuscular block by competing with this neurotransmitter. In France, only one type of device, called an accelerometer, is used to monitor curarization. This device couples electrical stimulation of a nerve with an accelerometer. Curarization can be said to be deep, moderate, residual or absent. Despite curarization appearing deep to the accelerometer, operating conditions do not always seem ideal for abdominal contraction. Indeed, the muscles tested with this device do not concern the muscles involved in laparoscopic surgery. A currently unexploited surgical parameter, variation in insufflation pressure, could change our approach to intraoperative curarization.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Poitiers University HospitalUpdated: Jun 18, 2025Duration: 3 Months
Eligibility criteria

Not listed

Status: Not yet recruiting

Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries

To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.

Participants needed: 75
Trial details
Age: 25-65Biological sex: AllType: InterventionalSponsor: Noor-Ul-AinUpdated: Apr 16, 2025Locations: 1
Eligibility criteria

1. Age Limit : 25 years to 65 years

1. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of...

Status: Recruiting

Predictors of Postoperative Complications in Surgery With Pneumoperitoneum in the Trendelenburg Position

Evaluate early postoperative complications after surgery in Trendelenburg position with increased intraabdominal pressure (surgery with pneumoperitoneum). Evaluate the relationship between hemodynamic and metabolic changes on perioperative outcome.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Reuven PizovUpdated: Apr 1, 2025Locations: 1
Eligibility criteria

ASA Class I-IV. [+2]

Pregnancy. [+2]

Status: Not yet recruiting

Low Pressure Pneumoperitoneum Using AirSeal® for Reduction in Postoperative Shoulder Pain Following Robot Assisted Hiatal Hernia Repair

The goal of this clinical trial is to evaluate the incidence and severity of post-operative shoulder pain following elective robot-assisted hiatal hernia repair in hopes of reducing pain and associated costs as well as clinic and emergency department visits due to this pain. You will undergo standard robot-assisted hiatal hernia repair with the standard postoperative care. The only difference is that you may be selected for the group where lower pressures used to fill your abdomen with carbon dioxide will be used, and you will be asked to fill out logs regarding your pain postoperatively. You will have postoperative appointments that are standard following this procedure.

Participants needed: 120
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Riverside University Health System Medical CenterUpdated: Dec 17, 2024Locations: 1
Eligibility criteria

patients undergoing elective robot assisted hiatal hernia repair

patients less than 18 years of age [+8]

Status: Recruiting

Comparison Between Low Pressure Pneumoperitoneum with High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Tip Pain and Common Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy

This study aims to address the existing gap in knowledge by conducting a comprehensive comparison of the incidence of pain and common bile duct injuries in patients undergoing laparoscopic cholecystectomy using Low pressure pneumoperitoneum versus high pressure pneumoperitoneum.

Participants needed: 82
Trial details
Biological sex: AllType: InterventionalSponsor: Gulab Devi HospitalUpdated: Dec 4, 2024Locations: 1
Eligibility criteria

Patients from both genders [+1]

Patients with cardiac abnormalities. [+1]

Status: Recruiting

Ultrasonography Guided Pneumoperitoneum for Laparoscopic Surgery in Morbidly Obese Patients

Bariatric Surgery for morbid obesity is indicated when BMI \> 40 kg/m2 without comorbidities or BMI \> 35 kg/m2 with co-morbidities. Different surgeries performed for obesity are classified as restrictive, malabsorptive, and hybrid procedures. Because laparoscopic surgery has increased the interest and growth of bariatric surgery, soaring demand for laparoscopic bariatric surgery from patients has boosted the boom in bariatric surgery worldwide. Achieving pneumoperitoneum is the initial and one of the most crucial steps in any laparoscopic surgery, giving the surgeon working space to operate on a particular organ/organ system. Usually, pneumoperitoneum is achieved either by a closed technique with a veress needle or an open technique with many variations like finger assisted or the conventional open technique. Given the excess amount of subcutaneous fat in morbidly obese patients, putting a veress needle to achieve pneumoperitoneum successfully is particularly challenging which takes a toll on the operating surgeon when he/she is trying to locate the midline one can either overshoot to cause omental emphysema or undershoot getting lost in the subcutaneous fat. It is usually done in the supra umbilical area. Sometimes, due to previous surgical scars other sites are preferred. Sonography is routinely used by radiologists with negligible radiation exposure. Anesthesiologists in the operating room have used it for many assisted procedures like central line insertion / giving nerve blocks. It can also be used in obese patients undergoing metabolic surgery to assist in creating pneumoperitoneum by a veress needle. Advantages of Intraoperative ultrasonography in this particular study : 1. To quantify the thickness of subcutaneous fat 2. To visualise the linea alba and guide the veress needle safely into the peritoneal cavity 3. Real-time visualisation of the pneumoperitoneum created 4. Avoid complications like omental emphysema, bowel or vascular injury

Participants needed: 40
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: All India Institute of Medical Sciences, BhubaneswarUpdated: Jul 30, 2024Locations: 1
Eligibility criteria

All patients in the age group of 18 -65 years undergoing laparoscopic bariatric... [+2]

Patients who don't give consent and do not understand the nature of the study [+1]