Relapsed Peripheral T-Cell Lymphoma

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Review clinical trials related to Relapsed Peripheral T-Cell Lymphoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) and Interferon (IFN) beta (β) genes (VSV-hIFNβ-NIS) in combination with cemiplimab in patients with T-cell lymphoma. A virus, called VSV-hIFNβ-NIS, which has been changed in a certain way, may be able to kill cancer cells without damaging normal cells. Immunotherapy with ipilmumab and cemiplimab may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread.

Participants needed: 21
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Mayo ClinicUpdated: Jul 1, 2026Locations: 2
Eligibility criteria

Age >= 18 years [+17]

Availability of and patient acceptance of curative therapy [+15]

Status: Recruiting

Pembrolizumab and Olaparib Treatment for Relapsed or Refractory Peripheral T-Cell Lymphoma

The goal of this clinical trial is to evaluate the efficacy and safety of Pembrolizumab in combination with Olaparib in participants with relapsed/refractory Peripheral T-cell Lymphoma (PTCL). The study mainly aims to evaluate: * objective response rate (ORR) as per Cheson response criteria assessed by the independent central review * overall survival and progression-free survival * adverse events by CTCAE version 5.0 The administration of Pembrolizumab and Olaparib to participants will occur on Day 1 of each 3-week dosing cycle and will continue until disease progression or unacceptable toxicity, up to 35 cycles. Treatment with Olaparib will proceed continuously from Day 1 of Cycle 1, in 3-week dosing cycles in parallel with Pembrolizumab, up to 35 cycles, unless specific withdrawal/discontinuation criteria are met. After the end of treatment, each subject will be followed for 30 days for adverse event (AE) monitoring (serious AEs \[SAEs\] will be collected for 90 days after the end of treatment or 30 days after the end of treatment if the subject initiates new anticancer therapy, whichever is earlier).

Participants needed: 24
Trial details
Phase: Phase 2Age: 21-99Biological sex: AllType: InterventionalSponsor: National Cancer Centre, SingaporeUpdated: Sep 5, 2025Locations: 1
Eligibility criteria

Male/female participants who are at least 21 years of age on the day of signing... [+25]

A WOCBP who has a positive urine pregnancy test within 72 hours prior to treatme... [+17]

Status: Recruiting

Chidamide and Duvalisibon for the Treatment of Refractory/Relapsed Peripheral T-cell Lymphoma

To determine the efficacy and safety of Chidamide combined with Duvalisib in the treatment of refractory/relapsed peripheral T-cell lymphoma.

Participants needed: 33
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital of Xiamen UniversityUpdated: Feb 19, 2025Locations: 1
Eligibility criteria

Peripheral T-cell lymphoma (PTCL) or NK/T-cell lymphoma confirmed by histopathol... [+6]

Patients with central nervous system (CNS) or meningeal invasion [+19]

Status: Not yet recruiting

Pralatrexate Combined With Chidamide Bridging Allogeneic HSCT for Refractory/Relapsed Peripheral T-cell Lymphoma

This is a multicenter, prospective study of Pralatrexate combined with Chidamide bridging Allogeneic Hematopoietic Stem Cell Transplantation for Refractory/Relapsed Peripheral T-cell Lymphoma

Participants needed: 25
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Peking University People's HospitalUpdated: Nov 6, 2024Locations: 1
Eligibility criteria

Patients fully understand the study, voluntarily participate in and sign on the... [+7]

NK/T-cell lymphoma; [+7]