Resilience, Psychological

14

Review clinical trials related to Resilience, Psychological. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities

The goal of this clinical trial is to learn if a personalized prenatal support program \[(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)\] works to lower stress and lower the risk of early delivery in pregnant individuals at high-risk for delivering preterm. The main question\[s\] it aims to answer are: * Does the PTBCARE+ patient support program lower patient-reported stress levels during pregnancy? * Does the PTBCARE+ patient support program improve biologic measures of stress during pregnancy? * Does the PTBCARE+ patient support program result in a higher chance of delivering a healthy baby at or close to full term? Researchers will compare people who participate in the PTBCARE+ patient support program to those receive usual care to see if the PTBCARE+ patient support program lowers patient-reported stress, improves biologic measures of stress, and increases the chance of delivering a healthy baby at or close to full term. Participants will be randomly assigned to receive the PTBCARE+ patient support program or usual prenatal care. All participants will be asked to: * complete 2 study visits during pregnancy - including completing electronic surveys, providing a blood and urine sample, measuring the heart rate variability by a clip or the ear or finger, and body composition evaluation using a simple scale-like device. * complete one study visit postpartum that includes completing electronic surveys, and measuring heart rate variability. Blood and urine sample collection and body composition evaluation via InBody scale are optional at the postpartum visit. People who are randomly assigned to receive the PTBCARE+ support program will receive several resources to help them during pregnancy. These things include items such as: * a stress reduction toolkit; * access to an online website that can also be downloaded as a smart phone app; * the option to receive an electronic massage while in clinic, and more. * additional support gifts provided at routine clinical appointments People who are randomly assigned to receive usual prenatal care will not receive any additional support resources from the study during pregnancy.

Participants needed: 1,228
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of North Carolina, Chapel HillUpdated: Jun 29, 2026Locations: 1
Eligibility criteria

Viable, singleton pregnancy, 8+0 to 19+6 weeks, dated by last menstrual period ±... [+18]

Participation in another intervention based clinical trial during pregnancy that... [+23]

Status: Recruiting

A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

The goal of this pragmatic clinical trial is to learn if the WE BEAT program, a 5-week group-based online wellbeing and skill-building program, can help teens with congenital heart disease (CHD) improve their ability to handle stress. The main question it aims to answer is if participants who receive the WE BEAT program become more resilient (the ability to bounce back from from tough times or recover from something difficult) and have better quality of life compared to participants who receive usual care. The study also aims to learn if there are connections between participant-reported psychosocial data (such as resilience, feelings about one's life and one's physical, mental, and social wellbeing) and clinical outcomes. Eligible participants who are 12-17-year-old will be in the study for about 6 months and be randomized to receive either the WE BEAT program or usual care. Following completion of the primary WE BEAT intervention at Week 5, intervention arm participants will be randomized to a single-session booster session (occurring at Week 18) vs no booster session. The booster session will be provided in a similar format to the WE BEAT program. A review of all modules/skills introduced in the program will be provided. All participants will complete 4 sets of online surveys and give 3 hair/saliva samples at different timepoints. Some participants may volunteer to give optional blood and urine samples.

Participants needed: 390
Trial details
Age: 12-17Biological sex: AllType: InterventionalSponsor: Carelon ResearchUpdated: Jun 22, 2026Locations: 14
Eligibility criteria

Age 12-17 years old [+4]

CHD of mild or simple complexity (Class I, 2018 AHA/ACC ACHD, Table 4) [+5]

Status: Not yet recruiting

Shame, Resilience and Well-being After Intimate Partner Violence: an Intervention Study With Replicated Single-Subject Design.

The EMBER protocol is a health care method that is designed to increase resilience, in order to improve well-being and overall health in women who have experienced violence by a partner. This study explores whether the EMBER intervention works in this way. Eight participants will take part in the EMBER program and complete questionnaires every week during the intervention. The researchers will compare the timeline for the intervention to how resilience levels change. They will also check whether changes in resilience are linked to changes in health and well-being.

Participants needed: 8
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Uppsala UniversityUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

subjected to IPV within 2 years prior to enrollment [+3]

ongoing severe IPV [+4]

Status: Not yet recruiting

Resilience and Recovery After Intimate Partner Violence - Evaluation of the EMBER-IPV Protocol

The EMBER-protocol is an intervention used at the NCK clinic at Uppsala University Hospital with the purpose of helping women utilize their resilience and strengths in order to recover after intimate partner violence. This study is conducted in order to explore how health and resilience changes during the course of the EMBER-intervention. The participants are asked to complete questionnaires before, during and after the intervention.

Participants needed: 150
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Uppsala UniversityUpdated: May 26, 2026Locations: 1
Eligibility criteria

Women taking part of the EMBER intervention (phase A or C) [+1]

Ongoing severe intimate partner violence [+2]

Status: Not yet recruiting

Evaluating a Digital Intervention to Improve Resilience and Reduce Stress in Stanford Populations

High-achieving academic and entrepreneurial populations face elevated risks of chronic stress, anxiety, and burnout. These populations often underutilize mental health services due to stigma, time constraints, or accessibility issues. Digital interventions provide an opportunity to deliver evidence-based stress and resilience support at scale. The WONE (Walking on Earth, Ltd.) platform integrates personalized stress-resilience assessments, behavioral science micro-interventions, and optional wearable data feedback. This project aims to evaluate the feasibility, engagement, and preliminary efficacy of the WONE digital intervention in multiple Stanford-affiliated cohorts.

Participants needed: 260
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Stanford UniversityUpdated: May 4, 2026Locations: 1
Eligibility criteria

Aged between 18 and 65 years with Stanford affiliation [+6]

Psychiatric hospitalization for a mental health crisis in the past 12 months. [+2]

Status: Recruiting

Game Intervention for Resilience

The goal of this clinical trial is to learn if a game-based intervention can enhance psychological resilience and promote positive affectivity in adults who have experienced major life stress. The main questions it aims to answer are: * Does the game-based intervention improve positive affectivity and mental health compared to a waitlist control group immediately after the intervention and at 3-month follow-up? * Are the mental health benefits of the game-based intervention mediated by improvements in positive affectivity over time? Researchers will compare the game-based intervention to an active control group and a waitlist control group to see if the game leads to better emotional and mental health outcomes. Participants will: * Be randomly assigned to the game-based intervention group, the psychoeducation intervention group (as active control group), or the waitlist control group * Engage with the assigned program for 10 days within two weeks * Complete psychological assessments before and after the intervention, and again at 3-month follow-up

Participants needed: 60
Trial details
Age: 23-35Biological sex: AllType: InterventionalSponsor: The University of Hong KongUpdated: May 1, 2026Locations: 1
Eligibility criteria

fluency in oral and written Cantonese or Mandarin; [+2]

formal diagnosis of any major psychiatric illnesses or history of suicidal behav... [+4]

Status: Recruiting

How a Resilience-Focused Intervention is Perceived by Women Subjected to Domestic Violence

At Uppsala University Hospital, there is an outpatient clinic for women subjected to intimate partner violence. In order to explore how patients experience the biopsychosocial resilience-based intervention in use at the clinic and how well the intervention fits the needs of the patients, 30 patients from different stages of their contact at the clinic and with diverse life situations and background are enrolled. The researchers will carry out individual in-person interviews, each lasting approximately 60 minutes, based on a semi-structured set of questions. The questions concern the participant´s life situation, resilience and self-perceived needs, how well the intervention has met those needs and how it was perceived by the participant. The interviews are audio-recorded and transcribed verbatim for thematic analysis.

Participants needed: 30
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Uppsala UniversityUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Enrolled in the EMBER intervention at the NCK outpatient clinic.

Any situation that, in the opinion of the Investigator, would compromise the saf...

Status: Recruiting

Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder

Depression is a common and serious mental health condition that affects mood, thoughts, behavior, and overall quality of life. It arises from a complex interaction of biological, psychological, and environmental factors. While depression is more frequently diagnosed in women, research suggests that men may experience and express depressive symptoms differently. Men are more likely to display symptoms such as irritability, anger, impulsivity, or increased alcohol use, and they may be less likely to seek professional psychological support due to social expectations and fear of stigma. Stigma-both self-stigma (internalized negative beliefs about having a mental illness) and perceived social stigma (concerns about being judged by others)-can negatively influence individuals' willingness to seek help and adhere to treatment. In addition, psychological resilience, defined as the ability to cope effectively with stress and adversity, may play an important role in how individuals experience depressive symptoms and respond to treatment. This study aims to compare women and men diagnosed with Major Depressive Disorder in terms of depression severity, gender-sensitive depressive symptoms, self-stigma, perceived social stigma, and levels of psychological resilience. It will also examine the relationships among these factors to better understand how gender-related differences influence the experience and management of depression. Findings from this study may contribute to improved recognition of gender-specific features of depression, reduction of stigma, and the development of more individualized and effective mental health interventions for both women and men.

Participants needed: 90
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Eskisehir Osmangazi UniversityUpdated: Mar 25, 2026Locations: 1
Eligibility criteria

Male and female patients aged 18 to 65 years [+2]

Intellectual disability [+4]

Status: Recruiting

Study: Tea(m)Time - Strengthening the Team Resilience of Hospital Staff Through the Tea(m)Time Intervention

Employees in hospitals are exposed to various stressors and can be at risk of psychological stress. To counteract this, resilience programs are increasingly being offered. Most interventions focus on individual resilience. In this study, the focus is on the resilience of teams. For this reason, this research paper will focus on the Tea(m)Time intervention. Tea(m)Time is a health promotion intervention that combines the risk assessment of mental stress with a focus on team resilience. In order to generate knowledge about the Tea(m)Time intervention, this study aims to identify factors that promote and inhibit its implementation and mediate its effectiveness. The aim is to gain insights into the promotion of resilience in teams. The aim is to conduct the survey of the participants in the intervention group and the control group at three different points in time.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Catholic University of Applied Sciences MainzUpdated: Mar 20, 2026Locations: 3
Eligibility criteria

be at least 18 years old [+3]

be younger than 18 years old [+3]

Status: Recruiting

Building Community Resilience Program

Established in 2021, NYCEAL consists of approximately 40 organizational partners and 120 Community Health Workers (CHWs). Over the next four years (2024-2028), NYCEAL will work with this network to implement the following intervention: Building Community Resilience Program (BCR). To assess the impact of this intervention, an implementation research framework will be used, and pre- and post-surveys conducted, and other process evaluation measures collected. Changes in outcomes measures such as stress, resilience, overall wellbeing, and other related outcomes for participants in the BCR program will be measured for community healthcare workers and/or frontline workers that receive educational workshops.

Participants needed: 168
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Icahn School of Medicine at Mount SinaiUpdated: Mar 9, 2026Locations: 1
Eligibility criteria

Able to consent [+6]

Incapacitated to an extent that they are unable to comprehend a conversation or... [+6]

Status: Not yet recruiting

CesiKids Trial: Enhancing Psychological Resilience in Adolescents With Cancer

This study will develop and evaluate a mobile-based co-design intervention (CesiKids) to enhance psychosocial resilience in hospitalized adolescents aged 12-18 diagnosed with cancer. The program will be created using Bronfenbrenner's Ecological Systems Theory and designed in collaboration with nurses, recovered adolescents, and parents. A randomized controlled design will be used. The intervention group will participate in a four-week structured program, while the control group will receive standard care. Psychosocial resilience and coping outcomes will be assessed at baseline, post-intervention, and follow-up. This research aims to offer an evidence-based, scalable model to support resilience among adolescents with cancer in clinical settings.

Participants needed: 36
Trial details
Age: 12-18Biological sex: AllType: InterventionalSponsor: Eskisehir Osmangazi UniversityUpdated: Nov 14, 2025Locations: 1
Eligibility criteria

Parents have provided informed consent after receiving information, [+6]

Receiving hematopoietic stem cell transplantation treatment, [+4]

Status: Recruiting

Enhancing Resiliency and Optimizing Readiness in Military Personnel

Security Force Assistance Brigades (SFABs) are specialized United States Army units formed to train, advise, assist, enable and accompany operations with allied and partner nations. Security Force Assistance Brigades are composed of roughly 800 senior military personnel, primarily commissioned and non-commissioned officers selected from regular Army units across a wide range of military specialties. Because of the high operational tempo (OPTEMPO) of these units, individual resiliency is of utmost importance in maintaining readiness to successfully execute critical, high-stress missions. Acceptance and Commitment Training (ACT) is an evidence-based intervention with strong potential to enhance resiliency by bolstering psychological flexibility along with other factors which have been demonstrated to optimize individual and group performance. This project will compare an Acceptance and Commitment Training-based resiliency-enhancement training program as compared to training as usual in 600 3rd Security Force Assistance Brigades soldiers stationed at Fort Hood in Killeen, Texas. Assessment measures related to resilience will be administered before and after training as well as before and after deployment. Assessments will be conducted at baseline, and every 4 months thereafter for a total of 16-months.

Participants needed: 600
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: The University of Texas Health Science Center at San AntonioUpdated: Nov 12, 2025Locations: 1
Eligibility criteria

Adult 18 or older [+1]

None

Status: Not yet recruiting

Combined Intervention of Long-term Letter Mentoring and Centralized Summer Camp by University Student Volunteers for Disadvantaged Children: A Randomized Controlled Trial

The goal of this clinical trial is to learn if a combined intervention of summer camp and letter-writing support works to improve psychological resilience in disadvantaged adolescents in Liangshan, Sichuan. The main questions it aims to answer are: Does the "summer camp + letter-writing" intervention improve resilience in adolescents who face poverty, lack of parental care, or social risks? Does this intervention reduce depression and anxiety symptoms? Researchers will compare adolescents who join the summer camp and receive monthly letters to those who do not receive this program to see if the intervention helps their mental health and coping skills. Participants will: Attend a 5-day summer camp that includes group games, emotion expression activities, life education, and learning support Receive monthly letters from trained university student volunteers for about 10 months after the camp. The letters will encourage them, give advice, and help them practice what they learned in the camp Complete surveys about their resilience, depression, and anxiety before the intervention, during it, at the end, and 6 months later This study will also look at whether the program is cost-effective, meaning if it brings mental health benefits at a reasonable cost.

Participants needed: 497
Trial details
Age: 10-16Biological sex: AllType: InterventionalSponsor: Xiaoxuan LiuUpdated: Jul 28, 2025
Eligibility criteria

Students enrolled in Grade 7 or Grade 8 (junior middle school) in selected schoo... [+5]

Children with serious psychiatric or developmental disorders (e.g., autism spect... [+4]

Status: Not yet recruiting

Effectiveness of Positive Psychological Intervention on Resilience Improvement in Nurses

The nursing profession, comprising over 27.9 million individuals and representing 59% of the health sector, plays a critical role in frontline healthcare globally. However, nurses face significant workplace stress due to factors like high mortality rates and ethical dilemmas, which can negatively impact their mental health. Resilience has emerged as a crucial concept in mitigating workplace stress and protecting nurses' psychological well-being. Studies show a negative correlation between stress and resilience, with higher resilience linked to better psychological outcomes and lower rates of burnout. Resilience, a dynamic process of positive adaptation to stress, can be enhanced through interventions like positive psychology, which focuses on developing traits such as perseverance, interpersonal skills, and emotional stability. These interventions have been shown to reduce burnout, improve job satisfaction, and potentially enhance patient care, making them vital in addressing the unique challenges nurses face. Gap of Knowledge: Although existing research has demonstrated the effectiveness of positive psychology interventions in reducing depression, anxiety, burnout, and stress among healthcare workers, including nurses, there is a need for more targeted randomized controlled trials (RCTs) that specifically address the unique stressors and work environments of nurses. Furthermore, the long-term effects of these interventions on nurses' resilience, stress, burnout, and job satisfaction require further exploration through well-designed RCTs. Research Aims and Hypothesis: The present study aims to 1. evaluate whether a positive psychology intervention, based on evidence-based activities from several positive psychology theories, can improve resilience in nurses, and 2. assess whether this intervention can also enhance stress levels, reduce burnout, and improve job satisfaction among nurses. The hypotheses are: 1. the positive psychology intervention will improve nurses' resilience; 2. the intervention will positively impact stress, burnout, and job satisfaction; and 3. it will be more effective for nurses with low resilience in improving these outcomes.

Participants needed: 80
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Fitria Endah JanitraUpdated: Aug 27, 2024Locations: 1
Eligibility criteria

registered nurses working in clinical settings [+2]

Recent exposure to severe illness, trauma, or major life events in the past thre... [+2]