Respiratory Distress Neonatal

5

Review clinical trials related to Respiratory Distress Neonatal. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Delayed Versus Immediate Cord Clamping in Preterm Birth

The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth. Preterm infants are at higher risk of neonatal complications, and the timing of cord clamping may influence placental transfusion and neonatal adaptation after birth. Delayed cord clamping may increase blood volume, improve iron stores, and reduce some neonatal morbidities, while immediate cord clamping is still commonly practiced in many settings. In this study, preterm newborns are assigned to either delayed or immediate cord clamping according to a predefined protocol. Early neonatal outcomes, including respiratory status, need for resuscitation, hemoglobin levels, and early morbidity and mortality, will be assessed. The study is conducted in a tertiary maternity center in Tunisia.

Participants needed: 200
Trial details
Age: 0+Biological sex: AllType: InterventionalSponsor: Faculty of Medicine of TunisUpdated: Jul 13, 2026Locations: 1
Eligibility criteria

Preterm neonates born at gestational age between 32 and 37 weeks [+3]

Major congenital malformations or chromosomal abnormalities [+4]

Status: Recruiting

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (\>6 hours of life).

Participants needed: 500
Trial details
Age: 32-41Biological sex: AllType: ObservationalSponsor: Mayo ClinicUpdated: Mar 18, 2026Locations: 1
Eligibility criteria

Neonates born at 32 completed weeks gestational age or older whose deliveries ar... [+1]

Neonates with known or suspected congenital anomalies [+3]

Status: Not yet recruiting

ADINA vs. High Flow Nasal Cannula Comparison Study

This study is to evaluate the feasibility of using a pressure limited nasal cannula system instead of a high flow nasal cannula system in the management of premature babies with respiratory distress.

Participants needed: 40
Trial details
Age: 23-40Biological sex: AllType: InterventionalSponsor: Loma Linda UniversityUpdated: Jan 30, 2026Locations: 1
Eligibility criteria

Neonates admitted to NICU [+3]

Intolerance to procedure [+13]

Status: Not yet recruiting

Comparison of the Silverman-Andersen Score and the Downes Score

This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as well as to evaluate the agreement of these scoring systems with other methods used to assess the severity of respiratory distress. The present study was designed as a prospective, multicenter, observational study conducted with neonates undergoing noninvasive ventilation.

Participants needed: 220
Trial details
Age: 2-12Biological sex: AllType: ObservationalSponsor: Muğla Sıtkı Koçman UniversityUpdated: Sep 19, 2025Locations: 4
Eligibility criteria

Preterm infants born at >28 weeks of gestation or term infants born at ≥37 weeks... [+5]

Major congenital malformations. [+10]

Status: Not yet recruiting

Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study

Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability. This pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.

Participants needed: 40
Trial details
Age: 1-7Biological sex: AllType: ObservationalSponsor: Medical University of GrazUpdated: Aug 12, 2025Locations: 2
Eligibility criteria

Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neo... [+2]

cardiopulmonary malformations [+2]