Rumination - Thoughts

2

Review clinical trials related to Rumination - Thoughts. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

NLP Analysis of Weekly Narratives for Dynamic Clinical Assessment in SUD

This prospective observational study follows adults undergoing residential rehabilitation for severe substance use disorders at a specialized treatment center in Mexico. Participants provide weekly written narratives describing their emotions, challenges, coping strategies, and treatment experiences, and complete validated psychological questionnaires every two weeks, including the Generalized Anxiety Disorder-7 (GAD-7), Environmental Reward Observation Scale (EROS), Automatic Thoughts Questionnaire-8 (ATQ-8), and Behavioral Activation for Depression Scale (BADS). The study applies natural language processing (NLP) and machine learning methods to analyze participants' narratives and identify emotional, cognitive, and behavioral patterns associated with clinical change over time. Narrative-derived features are combined with questionnaire scores to generate a dynamic clinical risk representation that may help detect early signs of psychological worsening or improvement during residential treatment. Participants continue receiving standard residential care, and the study does not modify treatment decisions or clinical interventions. Up to 35 participants with sufficient longitudinal follow-up data will be included in the primary analysis. Data collection is expected to continue through September 2026.

Participants needed: 35
Trial details
Age: 18+Biological sex: MaleType: ObservationalSponsor: Lauro Gutiérrez CastroUpdated: May 19, 2026Locations: 1Duration: 20 Weeks
Eligibility criteria

Clinical diagnosis of severe substance use disorder (polydrug use, including coc... [+6]

Presence of acute psychotic symptoms that interfere with the ability to write or... [+4]

Status: Not yet recruiting

Calming Minds Study

The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to: 1. Figure out what actually causes repetitive negative thinking to decrease when people use cognitive-behavioral therapy (CBT). 2. Find out which parts of RNT-focused CBT are the most important - the parts that truly make a difference in reducing RNT. The main result we will look at is how much a person's repetitive negative thought patterns change from the start of the study to the end of treatment (16 weeks). We will measure this using the Perseverative Thinking Questionnaire at baseline and week 16.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of California, Los AngelesUpdated: May 11, 2026Locations: 1
Eligibility criteria

Aged 18+ years [+4]

Concurrent psychotherapy [+7]