Severe Knee Osteoarthritis

2

Review clinical trials related to Severe Knee Osteoarthritis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis

This study aims to evaluate the acute effects of blood flow restriction (BFR) training on hypoalgesia and neuromuscular responses in patients with severe gonarthrosis by comparing the application of pressure with a dynamic versus a fixed configuration. There will be six different training conditions with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure; 3) 50% RM and 50% BFR with dynamic pressure; 4) 50% RM and 50% BFR with fixed pressure; 5) 30% RM and 80% BFR with dynamic pressure; 6) 30% RM and 80% BFR with fixed pressure. Each participant will complete six individual sessions under different training conditions, assigned in a random order with a 72-hour interval between each session.

Participants needed: 45
Trial details
Age: 50-85Biological sex: AllType: InterventionalSponsor: University of ValenciaUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

Age between 50 and 85 years [+2]

Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog... [+8]

Status: Recruiting

Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure

This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.

Participants needed: 45
Trial details
Age: 50-85Biological sex: AllType: InterventionalSponsor: University of ValenciaUpdated: Jun 10, 2026Locations: 2
Eligibility criteria

Age between 50 and 85 years [+2]

Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog... [+8]