Trismus

10

Review clinical trials related to Trismus. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

"Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery"

This study aims to determine whether giving a single dose of dexamethasone before surgery can reduce pain and difficulty in opening the mouth after removal of an impacted lower wisdom tooth. Pain and limited mouth opening are common problems after this procedure and can affect eating, speaking, and daily activities. A total of 268 patients aged 18 to 55 years who require surgical removal of an impacted mandibular third molar will be included. Participants will be randomly assigned to one of two groups. One group will receive a 4 mg dexamethasone injection under the gum before surgery, while the other group will not receive this medication. All patients will undergo the same surgical procedure and receive standard postoperative care. Pain will be measured using a visual analogue scale, and mouth opening will be assessed using a standard measuring method. These outcomes will be recorded on the second and seventh days after surgery. The results of this study will help determine whether preoperative dexamethasone is an effective and simple method to reduce postoperative discomfort and improve recovery after third molar surgery.

Participants needed: 268
Trial details
Phase: Phase 4Age: 18-55Biological sex: AllType: InterventionalSponsor: Hayat Abad Medical Complex, PeshawarUpdated: May 1, 2026
Eligibility criteria

Adults aged 18 to 55 years [+2]

Patients with systemic diseases [+4]

Status: Recruiting

Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus

Trismus, or restricted jaw movement, can occur in individuals with head and neck cancer (HNC) undergoing surgery or radiation therapy. There is a paucity of research examining interventions for trismus. We aim to assess the feasibility of prospective surveillance and early intervention to mitigate trismus in individuals undergoing HNC treatment. Method: The investigators will conduct a pilot single group feasibility study involving 30 individuals with HNC who will be undergoing radiation therapy. Participants will be identified at the HNC new patient clinic. Participants will be seen weekly during radiation therapy and will receive early intervention including manual therapy and a device-based jaw exercise regimen if presenting with 5% or greater reduction in jaw opening compared to pre-treatment. The investigators will assess recruitment and completion rates, intervention acceptability, and data collection procedures. Descriptive statistics will summarize feasibility metrics and participant demographics. Findings will inform the design of a larger multicentre trial.

Participants needed: 30
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of AlbertaUpdated: Apr 6, 2026Locations: 1
Eligibility criteria

Have a diagnosis of oral, oropharyngeal, or nasopharyngeal cancer [+3]

Previous surgery for the temporomandibular joint that is not related to the HNC... [+2]

Status: Recruiting

Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery

This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of impacted mandibular third molars. A total of 100 participants aged 18-40 years will be enrolled at the Dental Center, Medical City Hospital for Military and Security Services (MCMSS), Al Khoud, Oman. Participants will be randomly assigned to receive either Reparil® (Aescin 20 mg, three times daily for five days) or Ibuprofen (400 mg, three times daily for five days) following standardized third molar extraction procedures. Postoperative outcomes including pain (VAS), facial swelling (3D facial scanner), and mouth opening (digital caliper) will be assessed preoperatively, on day 2, and day 7 post-surgery. The study aims to determine whether Aescin offers comparable analgesic and anti-edematous effects to Ibuprofen with fewer adverse events.

Participants needed: 100
Trial details
Age: 18-40Biological sex: AllType: InterventionalSponsor: Oman Medical Speciality BoardUpdated: Jan 15, 2026Locations: 1
Eligibility criteria

Patients indicated for surgical removal of impacted mandibular third molars acco...

Recent use (within three weeks preoperatively) of anti-inflammatories, corticost...

Status: Not yet recruiting

Comparison of Two Different Suture Knot Techniques on Post-Operative Trismus and Swelling After Impacted Third Molar Surgery

To compare the two different suture knot techniques, locked and unlocked, in terms of mean on postoperative trismus and swelling after impacted mandibular third molar surgery.

Participants needed: 60
Trial details
Age: Up to 45Biological sex: AllType: InterventionalSponsor: Watim Medical & Dental CollegeUpdated: Jan 8, 2026Locations: 1
Eligibility criteria

• Healthy individuals [+4]

• Patients with ASA status III and above [+4]

Status: Recruiting

Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction

The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are: 1. Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction. 2. Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications. Participants will: For 7 days after the operation, they will gargle with chlorhexidine mouthwash or mouthwash containing tea tree oil 3 times a day. They will come to the clinic for check-ups and measurements on the 2nd and 7th days after the operation. They will record their pain levels and the number of painkillers they take daily.

Participants needed: 54
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Harran UniversityUpdated: Sep 18, 2025Locations: 1
Eligibility criteria

Individuals undergoing extraction of Class 2, Class B mandibular third molars im... [+3]

Individuals with a known allergy or hypersensitivity to tea tree extract. [+5]

Status: Recruiting

Hilotherapy vs. Kinesio Taping in Orthognathic Surgery Recovery

This prospective randomized controlled trial aims to compare the effects of kinesio taping and hilotherapy on postoperative edema, pain, and trismus in patients undergoing bimaxillary orthognathic surgery.

Participants needed: 36
Trial details
Age: 18-50Biological sex: AllType: InterventionalSponsor: Medipol UniversityUpdated: Jun 5, 2025Locations: 1
Eligibility criteria

Patients scheduled to undergo bimaxillary orthognathic surgery (Le Fort I + BSSR... [+3]

Presence of systemic disease or immunosuppressive medication [+3]

Status: Recruiting

Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer Survivors

Trismus has been reported as the second most common comorbidity in survivors of head and neck cancer (HNC). It is mainly associated with post-radiotherapy subcutaneous fibrosis, muscular atrophy, damage to neurological structures in the neck, or a combination of all, affecting masticatory musculature. In addition to this, the loss of flexibility and strength in the shoulder has also been shown to be related to deficits in the function and quality of life of these patients. The goal of this clinical trial is to determinate the effectiveness and safety of Manual Therapy (MT) on Oral Opening, Swallow Function, as well as the mobility of the upper quarter, the strength of cervical musculature, pain, functionality, and the perception of quality of life in head and neck cancer survivors. Participants will be assigned randomly to the study groups: a) manual therapy program and control motor exercises and b) motor control exercises (usual care). The assessment refers to a baseline form (at the beginning of the study), at 6 weeks and at 6 weeks of patient follow-up.

Participants needed: 70
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Universidad de La FronteraUpdated: May 30, 2025Locations: 2
Eligibility criteria

individuals with HNC [+5]

sequelae of previous stroke [+5]

Status: Recruiting

The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema

This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction. The main question it aims to answer is: Does dexamethasone submucosal injection have a positive impact on trismus and edema after third molar surgery compared to conventional postoperative prescription? Participants will: * Be administered with dexamethasone submucosal injection or a placebo after the surgery. * Visit the clinic three times the week after the extraction for follow-up.

Participants needed: 66
Trial details
Phase: Phase 4Age: 18-65Biological sex: AllType: InterventionalSponsor: King Abdulaziz UniversityUpdated: May 1, 2025Locations: 1
Eligibility criteria

Patients with impacted lower third molars requiring surgical extraction. [+2]

Patients with preoperative intraoral or extraoral swelling. [+5]

Status: Recruiting

Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy

Trismus is a common side effect in head and neck cancer patients after radiation therapy. This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients. In this project, Botulinum toxin will be injected into the masticatory muscles (medial pterygoid and masticatory muscles), combined with oral rehabilitation exercises, to reduce the patient's masticatory muscle tension and spasm. Patient's mouth opening range, quality of life, trismus condition and pain will be evaluated to understand its efficacy.

Participants needed: 120
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: National Taiwan University HospitalUpdated: Dec 16, 2024Locations: 1
Eligibility criteria

Aged over 18 years old; [+3]

Those who have undergone surgery on their masticatory muscles; [+3]

Status: Recruiting

Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery

The goal of this clinical trial is to evaluate whether the topical application of Novox® Drop on surgical wounds after the extraction of lower third molars can have a clinical advantage. The primary objective of the study is to evaluate the possible reduction of masseteric trismus (masticatory muscle spasm - primary outcome) and of post-operative pain and facial edema (swelling - secondary outcomes) after the extraction of impacted third molars compared to those who do not use it (placebo=glycerin-based gel).

Participants needed: 72
Trial details
Age: 18-35Biological sex: AllType: InterventionalSponsor: Azienda Ospedaliera di PerugiaUpdated: Jun 13, 2024Locations: 1
Eligibility criteria

good systemic and local health conditions of the patient; [+4]

diabetes mellitus; [+10]