Twin to Twin Transfusion Syndrome

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Review clinical trials related to Twin to Twin Transfusion Syndrome. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

The Efficacy of the KARL STORZ Curved Fetoscope and Straight Fetoscope for Laser Photocoagulation of Placental Anastomoses

The purpose of this study is to evaluate the efficacy of KARL STORZ curved fetoscope (11508AAK) and its straight version (11506AAK) for laser photocoagulation of placental anastomoses in patients with an anterior placenta and Twin to Twin Transfusion Syndrome (TTTS).

Participants needed: 160
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Jimmy EspinozaUpdated: Aug 14, 2025Locations: 1
Eligibility criteria

pregnancy [+4]

Contraindication to abdominal surgery, fetoscopic surgery, or general anesthesia [+7]

Status: Recruiting

Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery

This is a randomized trial for patients that are diagnosed with Twin-Twin Transfusion Syndrome (TTTS) who are receiving a fetoscopic laser surgery to evaluate the effectiveness and safety of a laparotomy closure.

Participants needed: 34
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Children's Hospital Medical Center, CincinnatiUpdated: May 28, 2025Locations: 1
Eligibility criteria

Diagnosis of TTTS or Twin Anemia-Polycythemia Sequence (TAPS) [+3]

Higher order pregnancies, chromosomal or severe congenital anomalies, undergoing...

Status: Recruiting

A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures

In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery. A fetoscope is like a small telescope that can see inside of the uterus (womb) during minimally invasive surgery. The curved scope is used for patients with an anterior placenta (front of uterus), while the straight scope is used for patients with a posterior placenta (back of uterus). The scopes will be used to assist in procedures involving fetoscopic laser photocoagulation (FLP), which is a minimally invasive surgery that uses a small camera (fetoscope) to locate abnormal blood vessel connections in the placenta and seal them off using laser energy. These fetoscopes will be utilized in the diagnosis and management of various fetal conditions that can arise during pregnancy. Outcome data will be reported in a descriptive statistical analysis. The investigators will assess the surgical outcomes, short and long-term morbidity, complications, and gestational age of participants in order to evaluate the benefit of using these devices.

Participants needed: 50
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Boston Children's HospitalUpdated: Sep 25, 2024Locations: 1
Eligibility criteria

Pregnant patient with a condition requiring in-utero surgery [+2]

Allergy or previous adverse reaction to any ancillary medication specified in th... [+6]