Type A Aortic Dissection

2

Review clinical trials related to Type A Aortic Dissection. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection

The goal of this multicenter, double-blind, randomized controlled trial is to learn if sivelestat sodium (Siv) can protect the organ function in patients suffered operation for acute type A aortic dissection. The main questions it aims to answer are: * Can the 3-day-treatment of Siv enlarge the Day-0-to-Day-5 drop in the organ-health score (SOFA score)? * Can this treatment significantly shrink the area under the SOFA curve from first dose to Day 5? * Can this treatment significantly improve the end of patients in 28 days (clinical outcomes)? Researchers will compare drug Siv to a placebo (a look-alike substance that contains no drug) to see if drug Siv works. Participants will: * Take drug Siv or the placebo through vein continuously for 72 hours * Receiving regular intensive care in ICU after the operation

Participants needed: 236
Trial details
Phase: Phase 4Age: 18-75Biological sex: AllType: InterventionalSponsor: Shanghai Zhongshan HospitalUpdated: Sep 5, 2025Locations: 6
Eligibility criteria

Age 18-75 years inclusive. [+2]

Life expectancy ≤ 48 hours. [+7]

Status: Recruiting

Safety and Efficacy of XJ-Procedure in Patients With Acute Type A Aortic Dissection Surgery

This is a national, multicenter, open-label, randomized, controlled, endpoint-blinded clinical trial of patients diagnosed with ATAAD and undergoing "Sun's procedure" coordinated by the First Affiliated Hospital of Xi'an Jiaotong University, China. Per the protocol, "Sun's procedure" combined with "XJ-Procedure" in the anastomosis of the aortic root and Sun's procedure combined with regular suturing methods of the aortic root will be compared.

Participants needed: 680
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: First Affiliated Hospital Xi'an Jiaotong UniversityUpdated: Jul 12, 2024Locations: 1
Eligibility criteria

Age 18-70 years; [+1]

Severe aortic root involvement (root diameter >45 mm, root tear, severe destruct... [+6]