Work Related Stress

12

Review clinical trials related to Work Related Stress. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain

Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments. Current occupational heat-stress guidelines aim to limit excessive increases in core body temperature and physiological strain through the use of work-rest schedules. However, these guidelines do not provide clear direction on the safe, maximum duration of continuous work that can be performed before heat-mitigation controls should be implemented, known as the initial stay time. Recent work has generated initial stay time recommendations for young and older workers performing moderate-intensity work in the heat, but these estimates were developed under normoxic conditions. In many occupational settings, workers may be exposed to additional environmental stressors such as hypoxia, including work at altitude or in oxygen-reduced environments. Hypoxia can increase cardiovascular strain, reduce arterial oxygen saturation, and alter exercise tolerance, potentially compromising the effectiveness of heat-stress guidance developed under normal oxygen conditions. Older workers may be especially vulnerable due to age-related reductions in thermoregulatory and cardiovascular function. To date, it remains unclear whether hypoxia alters physiological strain during work in the heat or whether current initial stay time and recovery recommendations remain protective under combined heat and hypoxic stress. The primary objective of this study is to determine whether exposure to hypoxia increases physiological strain during moderate-intensity work in the heat in young and older males. Specifically, investigators will assess whether normoxia-derived initial stay times and recovery recommendations for work at 29°C wet-bulb globe (37.5°C, 35% RH) temperature remain effective when workers are exposed to hypoxia equivalent to 14% inspired oxygen (simulating \~3000 m in altitude). Healthy young and older males will complete simulated occupational heat exposure under two conditions: heat alone and combined heat plus hypoxia. Participants will perform moderate-intensity treadmill work based on age-specific initial stay times, followed by prescribed work-rest cycles and seated recovery. Measures of core temperature, cardiovascular strain, oxygen saturation, skin temperature, hydration status, perceptual responses, mood, symptoms of environmental stress, and cognitive function will be assessed to determine whether hypoxia modifies responses to work in the heat. This study will provide important evidence on whether occupational heat-stress guidance requires refinement when workers are exposed to combined heat and hypoxic stress.

Participants needed: 20
Trial details
Age: 18-70Biological sex: MaleType: InterventionalSponsor: University of OttawaUpdated: Jun 24, 2026Locations: 1
Eligibility criteria

Are male. [+4]

Are regularly exposed to hot environments (e.g., occupational heat exposure) [+8]

Status: Not yet recruiting

Consecutive Occupational Heat Exposure With and Without Overnight Cooling

Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments. Current occupational heat-stress guidelines are designed to limit excessive increases in core body temperature and physiological strain during work in the heat through the use of work-rest schedules. However, these guidelines are largely based on single-day heat exposures and assume that workers recover in cool indoor environments between shifts. During heat events, many workers may instead recover in homes or accommodations that remain overheated, particularly in the absence of air conditioning. Inadequate overnight cooling may impair the body's ability to dissipate heat, increase physiological strain, and reduce tolerance to heat exposure on subsequent workdays. Older adults may be especially vulnerable due to age-related impairments in heat-loss capacity. To date, the effects of recovering in an overheated indoor environment on physiological strain and thermoregulatory function during repeated occupational heat exposure remain poorly understood, limiting the development of evidence-based recommendations to protect workers during prolonged heat events. The primary objective of this study is to determine whether overnight recovery in an overheated indoor environment increases physiological strain during repeated occupational heat exposure in older adults. Specifically, investigators will assess whether recovery at the recently proposed upper indoor temperature limit of 26°C and 45% relative humidity (RH) (PMID: 38329752) is sufficient to attenuate elevations in core temperature during subsequent work in the heat compared with recovery in an overheated indoor environment (31°C, 45% RH) representative of conditions commonly experienced during extreme heat events. Healthy older adults will complete two consecutive days and nights of simulated moderate-intensity occupational heat exposure, with overnight recovery occurring in either the 26°C or 31°C condition. Measures of core temperature, cardiovascular strain, heat-loss capacity, hydration status, sleep quality, cognitive function, mood, and perceptual responses will be assessed to determine the impact of overnight recovery conditions on responses to repeated heat exposure. Whole-body heat-loss capacity will also be evaluated before and after the exposure protocol as assessed during incremental, intermittent exercise protocol performed in an air calorimeter.

Participants needed: 10
Trial details
Age: 50-70Biological sex: MaleType: InterventionalSponsor: University of OttawaUpdated: Jun 18, 2026Locations: 1
Eligibility criteria

Are male. [+4]

Are regularly exposed to hot environments (e.g., occupational heat exposure) [+7]

Status: Not yet recruiting

XR2ESILIENCE - XR-Based Resilience Training for Stress and Mental Health in Healthcare Workers

This study investigates the effectiveness of an extended reality (XR) based resilience training program designed to support the mental health and well-being of nurses working in hospital settings. Nurses are exposed to high emotional, cognitive, and organizational demands and show elevated levels of work-related stress and stress-associated mental health problems. Strengthening resilience and coping capacities is therefore an important preventive approach to support nurses' well-being and sustain quality of care. The study is conducted as a pragmatic randomized controlled trial with a waitlist control group and includes approximately 232 nurses from hospitals in several European countries. Participants are randomly assigned either to an XR-based resilience training group or to a waitlist control group that continues with care as usual during the waiting period. The XR-based intervention consists of eight immersive training sessions delivered over approximately ten weeks using a head-mounted display. The training focuses on behavioral, cognitive, and emotional coping strategies and aims to enhance key resilience factors such as problem-solving, cognitive reappraisal, emotion regulation, and positive self-care. The primary outcome is perceived stress, assessed using the Perceived Stress Scale. Secondary outcomes include resilience, occupational self-efficacy, quality of life, psychological distress, burnout symptoms, coping strategies, work-related rumination, and turnover intentions. Assessments are conducted at baseline, post-intervention, and at a 20-week follow-up. In addition, a subgroup of participants will optionally provide physiological data during selected XR sessions to explore digital biomarkers related to stress and recovery. The findings of this study will provide evidence on the effectiveness, feasibility, and acceptance of XR-based resilience training for nurses and inform future implementation of digital mental health interventions in healthcare workplaces.

Participants needed: 232
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Medical University of GrazUpdated: May 18, 2026Locations: 8
Eligibility criteria

working as a nurse in direct patient care within a clinical setting; [+4]

a diagnosed severe mental disorder associated with alterations in reality percep... [+5]

Status: Not yet recruiting

A Mindfulness-based Intervention for Hotel Staff

This research aims to investigate the potential impact of a structured mindfulness-based professional development program on hotel employees and to explore why and how these changes occur during and after the mindfulness intervention through a mixed-methods approach. A 6-week mindfulness intervention with 60 hotel staff from a hotel will be implemented in Hong Kong. Both quantitative and qualitative data will be collected to examine changes in job-related outcomes, wellbeing, and state mindfulness and teachers' lived experiences and perspectives associated with this intervention. Data will be analyzed based on convergent parallel mixed-method approach, such as mixed-effects modeling, mediation analysis, and thematic analysis. This study may provide practical implications for developing evidence-based programs to promote wellbeing and service quality among hotel employees.

Participants needed: 60
Trial details
Age: 18-18Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Apr 30, 2026Locations: 1
Eligibility criteria

Aged 18 years or above [+3]

Individuals who had previously joined a related group mindfulness-based interven... [+1]

Status: Not yet recruiting

Virtual Mindfulness and Breathing Training for Stress, Burnout, Sleep, and Cognition in Rotating-Shift Nurses

This randomized controlled trial aims to evaluate the effectiveness of a mobile- and virtual reality-based mindfulness and breathing intervention on stress, burnout, sleep quality, and cognitive function among Rotating-shift nurses. Participants will be randomly assigned to one of four groups: (1) health education control group, (2) mobile-based mindfulness only, (3) mobile-based mindfulness combined with brief structured breathing, and (4) virtual reality-assisted mindfulness combined with brief structured breathing. The intervention will last for 8 weeks, with participants practicing 5 times per week for 10 minutes per session. Primary outcomes include perceived stress, burnout levels, sleep quality, and cognitive function.

Participants needed: 300
Trial details
Age: 20-65Biological sex: AllType: InterventionalSponsor: Chang Shih-ChinUpdated: Apr 8, 2026
Eligibility criteria

Age between 20 and 65 years. [+6]

Pregnant or breastfeeding individuals. [+8]

Status: Recruiting

Foundational Programs to Combat Clinician Stress

This is a prospective, randomized, controlled clinical trial in which clinicians from University of Pennsylvania Health Systems (UPHS) including Penn Medicine- Lancaster General Health (LGH) and Massachusetts General Hospital (MGH) are offered a well-known program to help reduce clinician burnout: Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation Intervention.

Participants needed: 180
Trial details
Age: 25-70Biological sex: AllType: InterventionalSponsor: Lancaster General HospitalUpdated: Oct 23, 2025Locations: 6
Eligibility criteria

25-70 years of age, [+5]

Currently maintaining a regular/daily mind-body program practice (eg. meditation... [+9]

Status: Recruiting

Stop for Stress - a Randomized Controlled Trial Comparing an Online and a Group-based Format of an Intervention for Work-related Stress

Work-related stress is a major public health concern, causing sickness absenteeism and impaired health and well-being. Many afflicted with severe work-related stress will not receive evidence-based treatment due to geographical distance, stigma and unwillingness to participate in a group, creating unequality access to healthcare services. Online interventions show comparable effects to face-to-face interventions and have potential to break down some of these barriers. We have developed and pilot tested the online delivery format of the intervention for work-related stress, Stop for Stress, with promising results. In a two-armed, multicentre randomized controlled trial we aim to 1) compare the effect of the online delivery format and an evidence-based face-to-face group-based format and 2) identify markers of enhanced outcomes in each delivery format. The study will include 220 patients with severe work-related stress (110 from each of two centres) who are randomizes 1:1 to the two interventions. Outcomes consist of self-report measures of psychological symptoms, cognitive functioning, sleep, and perceived working environment and register data on ebsenteeism and return-to-work.

Participants needed: 220
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Lea Nørgaard SørensenUpdated: Jun 17, 2025Locations: 2
Eligibility criteria

Current employment and significant work-related stressors [+3]

Interpersonal difficulties, bullying, harassment, violence, threats, and traumat... [+3]

Status: Not yet recruiting

Meta Self-efficacy Internet Intervention to Improve Work Self-efficacy and Occupational Well-being in Young Employees

This randomized controlled trial aims to test whether enhancing meta self-efficacy through a self-guided internet intervention improves young employees' work self-efficacy and occupational well-being. The trial will evaluate primary (work self-efficacy) and secondary (three dimensions of occupational well-being) outcomes. It is hypothesized that boosting meta self-efficacy will lead to improvements in outcomes, with effects assessed immediately after the intervention, and at 3- and 6-month follow-ups.

Participants needed: 600
Trial details
Age: 18-30Biological sex: AllType: InterventionalSponsor: University of Social Sciences and Humanities, WarsawUpdated: Apr 25, 2025Locations: 1
Eligibility criteria

must be between 18 and 30 years old [+1]

none

Status: Recruiting

Patient Acuity in Somatic In-patient Care

This study addresses nursing acuity measures within somatic in-patient care. Quantitative and qualitative analyses will be used in order to examine staffing levels and nurses' perception of work environment, before, during and after the implementation of a patient acuity tool as a part of daily management.

Participants needed: 250
Trial details
Biological sex: AllType: ObservationalSponsor: Region GävleborgUpdated: Apr 10, 2025Locations: 1
Eligibility criteria

All nurses employed by the medical wards [+1]

Travelling nurses [+1]

Status: Recruiting

Character-Strengths Based Coaching For Work-Stress Reduction For Health Workers

The purpose of this two-arm, parallel group individual randomized controlled trial is to evaluate the effectiveness of a character-strengths based coaching intervention consisting of a five-day residential workshop focusing on the use of character-strengths to address work-stress in routine situations supplemented by 8- to 10-week remote telephonic weekly coaching sessions to support rural health workers, as they face stressful situations and apply the strategies learnt in the workshop. The arms are: the character-strengths based intervention added to routine health worker supervision (weekly, by the supervisor) and routine supervision alone (control arm). The target sample comprises 330 government contracted 'ASHAs' (rural resident women, lay health workers) in the Sehore district of Madhya Pradesh, one of the most populous and poorest of the states in India. Scores on the 'Authentic Happiness Inventory (AHI)' will serve as the primary outcome for self-reported wellbeing and will be compared between arms at 3-month follow-up. Secondary ASHA-level outcomes will include assessment of self-reported affect, self-efficacy, flourishing, burnout, and motivation. We will also collect exploratory outcomes, including routine service delivery indicators to assess any effect of changes in well-being on ASHA's regular work performance, and resulting patient-level outcomes like satisfaction with services, and depression severity levels after receiving community-based depression care delivered by the ASHAs. We will also evaluate the costs of delivering the intervention and those incurred by ASHAs due to their participation in the intervention. Assessors blind to participant allocation will collect outcomes at baseline, 1-month and 3-month follow-up, as well as at 6-month follow-up, to ascertain differences in outcomes between arms. In addition, scores of ASHAs' self-perceived character strengths will be collected at baseline and 3-month follow-up as exploratory variables.

Participants needed: 330
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Templeton World Charity FoundationUpdated: Nov 20, 2024Locations: 1
Eligibility criteria

All rural ASHAs residing and working in Sehore district, Madhya Pradesh (verifie...

ASHAs who plan to migrate within six months of recruitment [+4]

Status: Recruiting

Leadership for Recovery: Evaluation of an Intervention Programme for First-line Healthcare Managers

The goal of this intervention study is to evaluate a group intervention programme that aims to support first-line healthcare managers in promoting their employees' recovery through a "leadership for recovery". In the study, the researchers will investigate if the intervention programme can improve the recovery (including sleep) of healthcare employees. The intervention programme consists of 6 group sessions for managers. The main question the study aims to answer are: \- Can a group-based intervention programme with a focus on strengthening first-line healthcare managers' leadership for recovery improve their employees' recovery? The intervention programme will be delivered to first-line healthcare managers in Swedish hospital care settings. Researchers will compare survey, diary and actigraphy data between employees of 1) managers who participate in the programme and 2) managers who has not participated in the programme.

Participants needed: 960
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Nov 18, 2024Locations: 2
Eligibility criteria

Not listed

Status: Recruiting

Stress and Musculoskeletal Health in Employees

This study aims to evaluate potential correlation of stress as estimated by certain biological markers, namely saliva cortisol, Heart rate variability (HRV), Electromyography (EMG) with musculoskeletal system health status, and assess the impact of a stress management intervention..The intervention group will be trained to apply two evidence based stress management techniques and they will be guided with tips and advice about musculoskeletal health. Impact of the intervention upon measured stress related markers will be assessed.

Participants needed: 57
Trial details
Age: 19+Biological sex: AllType: InterventionalSponsor: University of ThessalyUpdated: Jul 5, 2024Locations: 2
Eligibility criteria

Writing and reading greek. [+2]

Employees who are close to retirement (at least 2 years before) and those for wh... [+7]