Clinical trials

23

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ICP-538 in Healthy Subjects

This is a Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ICP-538 in Healthy Subjects

Participants needed: 104
Trial details
Phase: Phase 1Age: 18-50Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Jun 18, 2026Locations: 1
Eligibility criteria

Voluntarily sign the ICF.. [+4]

Evidence or history of clinically significant diseases, or Evidence or history o... [+15]

Status: Recruiting

Evaluate the Efficacy and Safety of ICP-488 in Subjects With Cutaneous Lupus Erythematosus (CLE) Double-blind Study

This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy and safety of ICP-488 in subjects with cutaneous lupus erythematosus (CLE).

Participants needed: 105
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Jun 8, 2026Locations: 27
Eligibility criteria

Aged ≥18 and ≤75 years. [+7]

Specific cutaneous lupus erythematosus subtypes: acute cutaneous lupus erythemat... [+2]

Status: Not yet recruiting

Evaluation of ICP-B208 in Patients With Advanced Solid Tumors

To evaluate the safety, tolerability, efficacy and pharmacokinetic characteristics of ICP-B208 in the trial participants of unresectable advanced or metastatic solid tumors

Participants needed: 539
Trial details
Phase: Phase 1, Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Jun 1, 2026Locations: 1
Eligibility criteria

18 years old to 75 years old; [+6]

Other active malignant tumors occurred within 3 years before the first administr... [+8]

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06)

This is a single-arm, multi-center, open-label, phase 2 study to evaluate the efficacy and safety of ICP-248 in subjects with relapsed or refractory mantle cell lymphoma.

Participants needed: 75
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Apr 27, 2026Locations: 29
Eligibility criteria

≥ 18 years old. [+6]

Blastoid or pleomorphic mantle cell lymphoma (MCL). [+4]

Status: Recruiting

Study of the Efficacy and Safety of ICP-332 in Participants With Chronic Spontaneous Urticaria

The purpose of this study is to compare the efficacy and safety of ICP-332 in moderate to severe chronic spontaneous urticaria subjects inadequately controlled by second generation H1-antihistamines

Participants needed: 344
Trial details
Phase: Phase 2, Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Apr 21, 2026Locations: 30
Eligibility criteria

1. Men and women aged 18 to 75 years. [+3]

1. Having the other medical conditions related to CSU or other skin diseases/con... [+3]

Status: Recruiting

Study of the Efficacy and Safety of ICP-332 in Participants With Prurigo Nodularis

Evaluate the efficacy and safety of ICP-332 in participants with Prurigo Nodularis (PN)

Participants needed: 135
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Apr 9, 2026Locations: 16
Eligibility criteria

Voluntarily sign informed consent forms before any investigational procedure(s)... [+6]

Patients with a documented AD severity moderate to severe presence of skin morbi... [+1]

Status: Recruiting

ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid Malignancies

Evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ICP-248 in combination with azacitidine in patients with acute myelogenous leukemia and Myelodysplastic Syndromes.

Participants needed: 266
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Apr 13, 2026Locations: 18
Eligibility criteria

Subject must have confirmation of diagnosis of AML (except for acute promyelocyt... [+6]

R/R AML or R/R MDS with no response or intolerance to post azacitidine or BCL-2i... [+5]

Status: Recruiting

Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis

This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study to evaluate the efficacy, safety, PK characteristics of ICP-488 in Chinese adults with moderate to severe plaque psoriasis.

Participants needed: 383
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Feb 9, 2026Locations: 46
Eligibility criteria

Subjects voluntarily participate in this study and have signed informed consent. [+4]

The diagnosis was non-plaque psoriasis. [+9]

Status: Recruiting

Efficacy and Safety of ICP-332 Versus Placebo in Participants With Moderate to Severe Plaque Psoriasis

The purpose of this study is to compare the efficacy and safety of ICP-332 to placebo in participants with moderate-to-severe plaque psoriasis.

Participants needed: 172
Trial details
Phase: Phase 2Age: 18-70Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Dec 31, 2025Locations: 1
Eligibility criteria

Subjects voluntarily participate in this study and have signed the Informed Cons... [+6]

Diagnosed with non-plaque psoriasis. [+5]

Status: Recruiting

ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (APEX-03)

Evaluate the safety, tolerability and pharmacokinetics of ICP-248 in Combination with Orelabrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Participants needed: 226
Trial details
Phase: Phase 2, Phase 3Age: 18-80Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Nov 21, 2025Locations: 53
Eligibility criteria

Age ≥ 18 and ≤ 80 years. [+8]

Central nervous system involvement. [+11]

Status: Recruiting

Efficacy and Safety of Orelabrutinib Combined With Rituximab Versus Lenalidomide Combined With Rituximab in Patients With Relapsed/Refractory Marginal Zone Lymphoma

Efficacy and Safety of Orelabrutinib Combined with Rituximab versus Lenalidomide Combined with Rituximab in Patients with Relapsed/Refractory Marginal Zone Lymphoma

Participants needed: 324
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 15, 2025Locations: 19
Eligibility criteria

Age ≥ 18 years , either sex. [+4]

Administration of the specified anti-tumor therapies within 2 weeks prior to the... [+4]

Status: Recruiting

Study of ICP-723 in Patients With Advanced Solid Tumors or Primary Central Nervous System Tumors

A Multi-center, Non-Randomized, Open-Label Phase 2 Basket Clinical Trial to Evaluate ICP-723 in Patients with Advanced Solid Tumors or Primary Central Nervous System Tumors

Participants needed: 70
Trial details
Phase: Phase 1, Phase 2Age: 2+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 11, 2025Locations: 1
Eligibility criteria

Eastern Cooperative Oncology Group (ECOG) performance status of 0-1; [+3]

Patients with unstable primary central nervous system (CNS) tumors or CNS metast... [+4]

Status: Recruiting

ICP-332 in Subjects With Moderate to Severe Atopic Dermatitis

A randomized, double-blind, placebo-controlled phase III study evaluating the efficacy and safety of oral ICP-332 in subjects with moderate to severe atopic dermatitis

Participants needed: 552
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 8, 2025Locations: 62
Eligibility criteria

Male or female subjects between 18 and 75 years of age. [+7]

Lack of response or inadequate response to prior treatment with any JAK inhibito... [+4]

Status: Recruiting

The Study of ICP-248 in Patients With Mature B-cell Malignancies

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ICP-248 as Monotherapy or in Combination Therapy in Patients with Mature B-cell Malignancies.This study consists of two parts: Part 1 dose-finding period and Part 2 dose expansion period.

Participants needed: 191
Trial details
Phase: Phase 1Age: 18-80Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 8, 2025Locations: 22
Eligibility criteria

Age ≥ 18 and ≤ 80 years. [+11]

Prior malignancy (other than the disease under study) within 2 years before stud... [+21]

Status: Recruiting

A Phase I/II Clinical Trial of ICP-723 in the Treatment of Advanced Solid Tumors

A Multicenter, Nonrandomized, Open-Label Phase I/IIClinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ICP-723 in Patients with Solid Tumors

Participants needed: 310
Trial details
Phase: Phase 1, Phase 2Age: 12+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 2, 2025Locations: 24
Eligibility criteria

Histopathologically confirmed surgically unresectable locally advanced or metast... [+6]

Any other active malignancy within 5 years prior to the first dose of the study... [+4]

Status: Not yet recruiting

Evaluation of ICP-B794 in Patients With Advanced Solid Tumors

An Open-Label, Multi-center, Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of ICP-B794 in Patients with Advanced Solid Tumors

Participants needed: 410
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Aug 22, 2025Locations: 1
Eligibility criteria

Age ≥18 years and ≤75 years. [+11]

Other active primary malignancies within 3 years prior to the first dose of inve... [+12]

Status: Recruiting

ICP-332 in Subjects With Non-segmental Vitiligo

This a phase II/III randomized, double-blind, placebo-controlled, parallel group, adaptive design, multi-center study to evaluate the efficacy and safety of ICP-332 in subjects with non-segmental vitiligo。The study consisted an phase 2 part and an phase 3 part.

Participants needed: 603
Trial details
Phase: Phase 2, Phase 3Age: 12-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Aug 7, 2025Locations: 45
Eligibility criteria

Male or female subjects aged ≥18 years and ≤75 years (Phase II portion). Male or... [+7]

Any of the following vitiligo related medical conditions and other skin diseases... [+3]

Status: Not yet recruiting

Evaluate the Safety, Tolerability, and Efficacy of ICP-490 in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

This is a multi-center, non-randomized and open-label phase I/IIa clinical study to evaluate the safety, tolerability, and efficacy of ICP-490 in patients with relapsed or refractory non-hodgkin lymphoma.

Participants needed: 68
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Feb 25, 2025Locations: 6
Eligibility criteria

Aged ≥ 18 years old. [+8]

Known active central nervous system (CNS) involvement Lymphoma. [+9]

Status: Recruiting

Safety, Tolerability, Pharmacokinetic Characteristics, and Efficacy of CM369 in Advanced Solid Tumors & Hematologic Malignancies

This is a nonrandomized, open-label, multicenter, phase I clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics, and efficacy of CM369 in subjects with advanced solid tumors and Hematologic Malignancies.

Participants needed: 146
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Dec 27, 2024Locations: 3
Eligibility criteria

Life expectancy ≥12 weeks. [+17]

Subjects with primary central nervous system (CNS) tumors or unstable CNS metast... [+32]

Status: Recruiting

Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Systemic Lupus Erythematosus

This is a phase IIb, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of orelabrutinib in adult subjects with SLE who are receiving standard of care (SOC) therapy.

Participants needed: 186
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Aug 16, 2024Locations: 41
Eligibility criteria

have had a detailed understanding of the nature, significance, potential benefit... [+6]

Pregnant or lactating women, and men or women who have birth plans in the past 1... [+19]

Status: Recruiting

Evaluate the Safety and Efficacy of Tafasitamab and Lenalidomide in Combination With Gemcitabine and Oxaliplatin Versus Rituximab in Combination With Gemcitabine and Oxaliplatin in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

This is a Randomized, Multi-center, Phase 3 Study of Tafasitamab and Lenalidomide in Combination with Gemcitabine and Oxaliplatin versus Rituximab in Combination with Gemcitabine and Oxaliplatin in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphom

Participants needed: 244
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Jul 25, 2024Locations: 20
Eligibility criteria

18 Years and older. [+9]

Existing or prior history of other malignant tumor within 3 years, except for th... [+10]

Status: Recruiting

A Study of ICP-192 in Patients With FGFR2-Rearranged Unresectable or Metastatic Intrahepatic Cholangiocarcinoma

This is a single-arm, open-label, multi-center phase 2 clinical trial of ICP-192. The purpose of this study is to evaluate the efficacy and safety in patients with FGFR2-Rearranged unresectable or metastatic intrahepatic cholangiocarcinoma who failed prior therapy

Participants needed: 70
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Feb 7, 2024Locations: 44
Eligibility criteria

Signed the ICF and Age ≥ 18 years old, either sex. [+7]

Presence of other malignancies requiring medical intervention. [+17]

Status: Recruiting

Evaluate the Safety and Efficacy of Tafasitamab Combined With Lenalidomide in Patients With Relapsed or Refractory DLBCL

This is a A Phase II, Single-Arm, Open-Label, Multicentre Study to Evaluate the Safety and Efficacy of Tafasitamab Combined with Lenalidomide in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Participants needed: 50
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Beijing InnoCare Pharma Tech Co., Ltd.Updated: Sep 23, 2022Locations: 1
Eligibility criteria

Age >18 years. [+5]

Patients who have other histological type of lymphoma,primary refractory DLBCL,a... [+15]