Clinical trials

7

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

TH-CAR-027 for Grade 4 Gliomas

This is an open-Label, dose-escalation, multiple administration, exploratory clinical study to evaluate the safety, tolerability, and anti-tumor activity of TH-CART-027 cell injection in subjects with recurrent or progressive grade 4 glioma

Participants needed: 21
Trial details
Phase: Early Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Feb 4, 2026
Eligibility criteria

1. Voluntarily participate in the clinical trial; fully understand and are infor... [+4]

Seropositivity for HIV antibody or positive serological test for Treponema palli... [+11]

Status: Recruiting

Multi-omics Characterization and Model Construction of Colchicine Anti-inflammatory Therapy Efficacy in ACS Patients

The aim of this prospective cohort study was to investigate the multi-omics characteristics of the efficacy of colchicine treatment in patients with ACS and to construct a model of efficacy. The main questions the study aims to answer are \- Specific mechanisms of colchicine therapy in patients with ACS; Mechanism-based modelling to identify the population that benefits from colchicine treatment.

Participants needed: 380
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Sep 15, 2025Locations: 1
Eligibility criteria

Between the ages of 18 and 80 [+3]

Any contraindication to colchicine or known intolerance to colchicine [+11]

Status: Not yet recruiting

A Clinical Study Exploring Universal CAR-T Cell in Patients With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

A Clinical Study to Investigate the Safety, Efficacy, and Cellular Metabolism of CT119X(including CT1190-P and CT1192) CAR-T Cell therapy, in Patients with Relapsed/Refractory B-cell acute lymphoblastic leukemia.

Participants needed: 36
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Jun 29, 2025Locations: 1
Eligibility criteria

Participants must voluntarily sign the informed consent form (ICF) and must be w... [+6]

Pregnant or lactating women; [+9]

Status: Recruiting

Efficacy and Safety Evaluation of U01(ssCART-19) in B-Cell Lymphoma

This is an open-label phase1 study to assess the safety and efficacy of U01(ssCART-19) cell therapy in the treatment of patients with refractory or recurrent B-cell lymphoma .

Participants needed: 50
Trial details
Phase: Phase 1, Phase 2Age: 2-75Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Jun 5, 2025Locations: 1
Eligibility criteria

Participants must voluntarily sign the informed consent form (ICF) and demonstra... [+8]

Uncontrolled infections (bacterial, fungal, viral, mycoplasmal, or others) as de... [+7]

Status: Not yet recruiting

An Exploratory Clinical Study of the Efficiency and Safety of TH027 in the Treatment of Relapsed/Refractory Solid Tumors

This is a Phase l, Open-Label, Dose-escalation Study to Evaluate the Safety, Tolerabilityand Antitumor Activity of TH027 CAR-T Cell lnjection (TH-CART-027) in Subjects With Relapsed or Refractory Solid Tumors.

Participants needed: 24
Trial details
Phase: Early Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: May 13, 2025Locations: 1
Eligibility criteria

1.The patients were aged from 18 to 75 years old (including the cut-off value),... [+11]

1.Patients with history of immune deficiency or autoimmune diseases (including b... [+11]

Status: Not yet recruiting

An Exploratory Clinical Study Evaluating the Safety and Efficacy of Intravenous Anti-CD20/CD30-CAR-T Cell Infusion in Relapsed/Refractory Lymphoma Patients.

This study is a single-center,open-label,single-dose clinical trial of anti-CD20/CD30-CAR-T cell therapy in relapsed/refractory B-cell tumor patients after lymphocyte depletion pre-treatment. In this study phase,a traditional "3+3"trial design is employed for dose escalation.

Participants needed: 12
Trial details
Phase: Early Phase 1Age: 18-70Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Jul 25, 2024
Eligibility criteria

Best response of Stable Disease (SD) after at least 4 cycles of first-line treat... [+22]

Evidence of central nervous system lymphoma on brain MRI; active primary central... [+6]

Status: Recruiting

Anti-CD19-CAR-T Cells in Relapsed/Refractory B-cell Tumor Patients.

This study is a single-center, open-label, single-dose clinical trial of anti-CD19-CAR-T cell therapy in relapsed/refractory B-cell tumor patients after Qinglin pre-treatment. In this study phase, a traditional "3+3" trial design is employed for dose escalation.

Participants needed: 12
Trial details
Phase: Early Phase 1Age: 18-70Biological sex: AllType: InterventionalSponsor: Shanghai Tongji Hospital, Tongji University School of MedicineUpdated: Apr 19, 2024Locations: 1
Eligibility criteria

Voluntary participation in the clinical trial; the individual or legal guardian... [+10]

CD19-targeted therapy. [+14]