Clinical trials

This randomized controlled trial (RCT) aims to evaluate the physical and physiological demands, the feasibility and the health, physical fitness and disease-specific outcomes of a progressive recreational team handball-based programme in patients with lower extremity peripheral arterial disease and intermittent claudication. The primary outcomes will be changes in functional capacity, assessed by the 6-minute walk test. Participants will be randomized to either a 24-week progressive team handball-based intervention or a usual care control group, with assessments performed at baseline, 12 weeks, and 24 weeks post intervention to evaluate health, physical fitness, and disease- specific outcomes.

The stretch-shortening cycle (SSC) is a fundamental mechanism in explosive human movement, enabling musculotendinous units to store and release elastic energy, thereby allowing the body to produce higher forces and velocities with greater mechanical efficiency. Movements such as sprinting, jumping, hopping, and sudden changes of direction, which depend on rapid force application, are supported by an effective SSC. Because of this, identifying a simple and interpretable index of SSC function has long been a priority in both research and applied sport settings. The Reactive Strength Index (RSI), most commonly defined as the ratio of jump height to ground contact time, has become the most widely used metric for quantifying SSC performance. However, this ratio presents notable methodological limitations: it combines variables of incompatible dimensions and is insensitive to drop height, thereby ignoring the eccentric load imposed on the musculotendinous system. The Dynamic Rebound Index (DRI), recently proposed as a dimensionless and mechanically grounded alternative, is calculated as DRI = (box height + jump height) / (9.8 × ground contact time²). Despite its theoretical advantages, a direct comparison between the RSI and DRI remains unexplored in the literature, which justifies the relevance of the present study. This study aims to compare the RSI and the DRI in physically active adults of both sexes during the execution of the Drop Jump at four different drop heights (20, 30, 40, and 50 cm). The specific objectives are: (a) to characterize performance across the four height conditions; (b) to analyze differences between sexes in both indices; (c) to examine the effect of drop height on both indices; and (d) to explore the informative complementarity between the two indices.

This study aims to examine the acute effects of an elastic band warm-up on sprinting and vertical jump performance in female football players. A crossover design will be used across three separate sessions: (1) standardized warm-up (WU), (2) warm-up followed by elastic band activation (WU + EB), and (3) elastic band activation followed by the warm-up (EB + WU). Performance evaluations-including sprint time and vertical jump height and power-will be conducted at three time points during each session: baseline (before the warm-up), immediately after the warm-up intervention, and 10 minutes post-intervention. This structure will allow the study to compare the immediate and short-term effects of different warm-up sequences involving elastic bands on neuromuscular performance. The findings may help optimize warm-up strategies to enhance acute athletic performance in female football players.

One of the recommended treatments for breast cancer is neoadjuvant chemotherapy (NCT), however, only 20% of the patients subject to this therapy present pathologic complete response (pCR). If exercise-induced tumour size reductions observed in preclinical studies translates to humans, physical training could emerge as a way of increasing rates of pCR to NCT, which would be a valuable clinical achievement. The present randomized controlled trial primary aim is to assess the impact of a physical exercise intervention the NCT efficacy. Following a parallel-arm design, 86 women with primary BC will be allocated 1:1 to a NCT + exercise (experimental) or NCT alone (control) group. The primary outcome is the rate of pCR in each group. Secondary outcomes include treatment tolerability and compliance, tumour infiltrating lymphocytes, ki67, immune, inflammatory, matricellular and myogenic markers, physical fitness, accelerometry, quality of life and body composition.

The goal of this clinical trial is to assess the effects of a 6-week strength training program with elastic bands on several physical components in adult female football players. The main question it aims to answer is: Will a specific elastic band resistance training help improve some components of physical performance in adult female football players? Participants will perform a bi-weekly elastic band resistance training, during a period of 6-weeks. This program will be incorporated into their in-season regimen, before their training session.