The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants. The main question it aims to answer is:
Do maternally derived strains of bacteria perform better than commercially available probiotic strains in restoring the gut microbiota of C-section born infants? Researchers will compare the gut microbiota of treated infants to that of untreated C-section born infants and untreated vaginally born infants to see if the bacterial treatments cause the microbiota to resemble that of vaginally born infants.
Participants will be given a bacterial product orally once daily for either one or four weeks and be asked to collect faecal, urine and saliva samples.
Healthy mother and healthy pregnancy
Singleton pregnancy,
Mothers who speak Finnish or Swedish
Mothers who are planning to breastfeed or give breastmilk by bottle to the infant
Participants who lives further than a 2-hour drive from Meilahti, Helsinki, Finland
Mothers who are not planning to breastfeed or feed breastmilk by bottle to the infant
Mothers who are diagnosed with gestational diabetes, pre-eclampsia or who have been receiving antibiotics during the pregnancy or delivery
Premature infants born before the pregnancy week 37
6
Treatment groupsSee each treatment group below.
University of Helsinki
Lead sponsor
Helsinki University Central Hospital
Collaborator