Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women
Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age50-70
SponsorBadr University
About this trial
This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program. Participants will be randomly allocated into either a study group receiving metformin iontophoresis or a control group receiving placebo iontophoresis. Both participants and outcome assessors will be blinded to group allocation.
Eligibility criteria
Qualifiers
• Postmenopausal women aged 50-70 years.
Clinical and radiographic diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria.
Radiographic severity classified as Kellgren-Lawrence grade II or III.
Chronic knee pain for a duration of at least 3 months.
Disqualifiers
• Severe knee osteoarthritis (Kellgren-Lawrence grade IV).
History of knee surgery or intra-articular injections within the previous 6 months.
Presence of inflammatory rheumatic diseases such as rheumatoid arthritis or gout.
Neurological disorders affecting lower limb function.
Trial design
Treatments tested in this trial
- Metformin gel Iontophoresis
- Iontophoresis
Treatment groups
68 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov