The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO)
The main question the platform trial aims to address is to determine the effect of a range of interventions on survival, organ support and resource utilisation to day 28 for hospitalised patients receiving ECMO.
Researchers will compare various interventions within multiple platform trial domains to see if the interventions have effects on survival, organ support and resource utilisation for the patient cohort.
Participants will be enrolled in accordance with the platform trial's domain structure to answer the research questions.
Patients receiving ECMO
Patients enrolled in the EXCEL Registry - NCT03793257
Treating clinician regards death as imminent and inevitable
Treating clinician determines it is not in the patient's best interests
Contraindication to RBC transfusion (including known patient preference)
Limitations of care put in place either through patient wishes or the treating medical teams.
Australian and New Zealand Intensive Care Research Centre
Lead sponsor
Monash University
Collaborator
Berry Consultants
Collaborator
Research Path
Collaborator