the Effect of Monk Fruit and Splenda on Salivary Ph and Streptococcus Mutans Count in Vivo Study

ConditionCaries Active
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-24
SponsorAl-Mustansiriyah University

About this trial

This study aims to evaluate the changes in salivary pH and Streptococcus mutans count by preparing a solution containing these sweeteners dissolved in distilled water and administering it to the participants. Saliva samples will be collected before using the mouth rinse, and salivary pH will be measured using a pH meter, while S. mutans count will be analyzed in the laboratory.

After consuming the solution, salivary pH will be assessed at 1 minute, 15 minutes, and 30 minutes, while the growth of S. mutans will be examined 30 minutes post-rinse.

Eligibility criteria

Qualifiers

No active carious lesions or oral diseases.

Generally healthy individuals without systemic illnesses.

No prior use of preventive dental treatments

Disqualifiers

Participants currently undergoing dental treatment.

Those taking medications that alter saliva flow.

Presence of painful oral conditions or systemic diseases. Participants have active caries

Trial design

Treatments tested in this trial

  • Monk fruit sweetener mouth rinse
  • Splenda (sucralose) sweetener mouth rinse
  • Sucrose mouth rinse

Treatment groups

90 Participants
are divided into 3 treatment groups

Sponsors and collaborators