This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.
None
The tooth has had previous endodontic treatment.
The root apex is not fully developed, or there is root resorption/cracking/fracture.
The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.
The root canal is calcified.
University of Medicine and Pharmacy at Ho Chi Minh City
Lead sponsor
Odonto-Maxillo Facial Hospital in Ho Chi Minh City
Collaborator