Clinical trials

8

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES

The study aims to assess the efficacy of culturally adapted dialectical behaviour therapy (DBT) for addressing emotional dysregulation in a low- and middle-income country, as well as to evaluate the impact of DBT on secondary outcomes such as borderline personality traits, self-harm or suicide, depression, anxiety, and individuals' functioning and disability. Through a rigorous Randomised Controlled Trial (RCT), the research seeks to assess how cultural adaptations of dialectical behaviour therapy improve its applicability, engagement, and outcomes in diverse socio-cultural settings, contributing to more accessible and effective mental health interventions in resource-limited regions.

Participants needed: 220
Trial details
Age: 18-45Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Nov 28, 2025Locations: 1
Eligibility criteria

Adults aged 18-45 years [+2]

Severe psychiatric comorbidity (e.g., active psychosis, substance use, etc.) [+2]

Status: Not yet recruiting

Effectiveness of a Guided Self-Help CBT Manual 'KOK' in Cancer Patients

This study aimed to assess the feasibility, acceptability, and preliminary efficacy of the Guided self-help CBT intervention 'Khushi or Khatoon' to treat anxiety and depression, and enhance quality of life and satisfaction with treatment in cancer patients.

Participants needed: 108
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Dec 1, 2025Locations: 1
Eligibility criteria

Adults (≥ 18 years) [+4]

Severe psychiatric conditions requiring immediate intervention/hospitalisation [+3]

Status: Not yet recruiting

Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for OCD

This randomised controlled trial (RCT) aims to assess the feasibility, acceptability, and preliminary efficacy of a culturally adapted, guided self-help cognitive behaviour therapy (CBT) manual specifically designed for individuals with OCD in Pakistan.

Participants needed: 108
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Nov 20, 2025
Eligibility criteria

Age ≥ 18 years [+5]

Current substance use or dependence (diagnosed) [+2]

Status: Not yet recruiting

Structured Group Therapy in Reducing Depression and Anxiety in Pakistan

This study aims to assess the effectiveness of Cognitive Behavioural Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR) in group settings to reduce symptoms of depression and anxiety, enhance emotional resilience, and improve social support among Pakistani individuals struggling with these conditions.

Participants needed: 108
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Nov 20, 2025Locations: 1
Eligibility criteria

Adults (18-65 years) [+3]

Severe psychiatric disorders (e.g., psychosis, bipolar disorder) [+3]

Status: Recruiting

Brief Culturally Adapted CBT for OCD

The purpose aims to assess the efficacy of Brief Culturally Adapted Cognitive Behaviour Therapy (Ca-CBT) for the treatment of Obsessive Compulsive Disorder (OCD).

Participants needed: 166
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Nov 18, 2025Locations: 1
Eligibility criteria

Participants aged 18 years or above [+2]

Participants with excessive use of alcohol or drugs (using ICD-10 RDC for alcoho... [+2]

Status: Recruiting

Feasibility and Acceptability Trial of a Culturally Adapted Manual Versus Standard CBT Manual: A Randomized Control Trial

This randomized controlled trial (RCT) will compare the efficacy and feasibility and acceptability of a culturally adapted CBT manual with a standard CBT manual, focusing on addressing cultural factors in therapy delivery.

Participants needed: 200
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Oct 17, 2024Locations: 1
Eligibility criteria

Individuals aged 18 to 65 years [+2]

Substance use disorder according to DSM-5 criteria as determined by primary care... [+2]

Status: Recruiting

Translation and Cultural Adaptation of the Dysfunctional Attitude Scale (DAS) Into Urdu

Translate and adapt the Dysfunctional Attitude Scale (DAS) into Urdu language and establishing the psychometric properties (reliability, validity, and norms) of the translated scale

Participants needed: 620
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Sep 19, 2024Locations: 1
Eligibility criteria

Substance use disorder according to DSM-5 TR criteria Significant cognitive impa...

Status: Recruiting

Can Cognitive Therapy Rating Scale (CTRS) be Used Across Cultures? Enhancing Cultural Relevance of CTRS

Translate and adapt the Cognitive Therapy Rating Scale (CTRS) into Urdu language and establishing the psychometric properties (reliability, validity, and norms) of the translated scale

Participants needed: 20
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Pakistan Association of Cognitive TherapistsUpdated: Sep 19, 2024Locations: 1
Eligibility criteria

Individuals aged 18 to 65 years At least 5 years of education Score of 8 or high...

Substance use disorder according to DSM-5 TR criteria Significant cognitive impa...