Mental Health Wellness 1

23

Review clinical trials related to Mental Health Wellness 1. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Emotional Recovery Post-Stroke

The purpose of this study is to evaluate whether adding an emotional wellness component to occupational therapy (OT) and/or speech therapy (ST) telerehabilitation improves overall emotional well-being and activity participation for people with stroke.

Participants needed: 80
Trial details
Age: 21+Biological sex: AllType: InterventionalSponsor: Medical University of South CarolinaUpdated: Jun 18, 2026Locations: 1
Eligibility criteria

Self-reported stroke-related deficits in emotional wellness such as anxiety, sle... [+7]

Unable to follow 1-2 step instructions given by the study team member during the... [+2]

Status: Recruiting

Future Leaders Program: Testing a Youth Leadership, Engagement, and Mindfulness Program

The current study tests the feasibility and effectiveness of a youth intervention designed to provide meaningful leadership opportunities through the acquisition of leadership skills as well as mindfulness practice, LEAP: Leadership, Engagement, and youth Action Program with Mindfulness. The goal of this project is to determine whether the Leadership, Engagement, and youth Action Program with Mindfulness (LEAP) curriculum, which was developed with youth, is a feasible and effective intervention for fostering leadership and well-being. The investigators seek to understand whether LEAP can support wellbeing for youth as a strategy to increase youth mental, emotional, and behavioral (MEB) health.

Participants needed: 504
Trial details
Age: 14+Biological sex: AllType: InterventionalSponsor: Boston University Charles River CampusUpdated: Jun 4, 2026Locations: 3
Eligibility criteria

Adolescents ages 14 and older in grades 9-12 during the Fall/Winter or in grades... [+2]

They participated in the pilot phase (UG3) [+3]

Status: Recruiting

Parenting in 2 Worlds Multisite Trial

This research study will test the effectiveness of a culturally grounded parenting intervention called Parenting in 2 Worlds (P2W). This intervention is designed for American Indian / Alaska Native (AI) parents/guardians of adolescents who reside in urban areas. This will be a multi-regional effectiveness trial across four regions: Northeast (Buffalo/Niagara), Midwest (St. Paul/Minneapolis), Mountain (Denver), and Southwest (Phoenix). There are four specific aims. First, this study will test the effectiveness of Parenting in Two Worlds (P2W) as compared to an informational family health intervention, Healthy Families in 2 Worlds (HF2W), in improving parenting and family functioning. Second, this study will test if the relative effectiveness of P2W, compared to HF2W, varies by parent's/guardian's level of socioeconomic vulnerability, experiences of historical loss, or AI cultural identity. Third, this study will examine if P2W can reduce adolescent (ages 12 - 17) risky health behaviors including substance use, depressive symptoms, suicidality, and risky sexual behaviors. Fourth, this study will examine whether positive changes in parenting and family functioning that result from P2W lead to positive changes in adolescent's health behaviors.

Participants needed: 1,440
Trial details
Phase: Phase 2Age: 12+Biological sex: AllType: InterventionalSponsor: Arizona State UniversityUpdated: Apr 29, 2026Locations: 4
Eligibility criteria

Must be American Indian parents or guardians of American Indian children aged 12... [+6]

Not applicable

Status: Recruiting

Randomized Controlled Trial on Precision Mental Health

The current study aims to evaluate the effectiveness of different online psychological interventions, including guided and unguided transdiagnostic cognitive behavioural therapy, and unguided mindfulness-based intervention, on mental well-being in comparison to waitlist control. It is hypothesized that participants with the guided psychological intervention will show (H1) a greater reduction in mental health symptoms, and (H2) better mental well-being compared with participants with unguided psychological intervention and the control condition.

Participants needed: 320
Trial details
Age: 17+Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Mar 25, 2026Locations: 1
Eligibility criteria

17 years old or above [+4]

People who are under 17 years old [+4]

Status: Not yet recruiting

Camouflaged WeChat-based Intervention for Abused Women

Intimate partner violence (IPV) is a major public health issue and human rights threat worldwide, especially for Chinese immigrant women victims in Hong Kong. Interventions that address negative physical and emotional outcomes from IPV could therefore play a crucial role in enhancing empowerment, social support, and healthy lifestyle among these women. The overall objective of this pilot mixed methods study is to determine the feasibility and acceptability of a camouflaged WeChat mini-program-based WOMEN Health intervention for women victims of IPV. This study will evaluate the feasibility and acceptability of a camouflaged WeChat mini-program-based WOMEN Health intervention for women victims of IPV.

Participants needed: 86
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: The University of Hong KongUpdated: Feb 12, 2026Locations: 1
Eligibility criteria

Chinese-speaking (Mandarin or Cantonese) [+5]

unwilling to provide informed consent [+2]

Status: Recruiting

Integrative Adolescence Research Programme (IARP)

This study aims to understand child health during adolescence. We will examine the role of lifestyle (e.g. physical activity), growth trajectories and other environmental factors that can influence the development of phenotypes in adolescence which confer risk for later physical and mental disorders. With this study, we will develop a deeper understanding of adolescent health and well-being and their main determinants in the local Singaporean context, identify levers for early interventions to mitigate challenges to adolescent health and well-being and enhance protective factors for adolescents to do well in life, contribute to society and maximize their potential.

Participants needed: 1,200
Trial details
Age: 13-15Biological sex: AllType: ObservationalSponsor: Institute for Human Development and Potential (IHDP), SingaporeUpdated: Dec 30, 2025Locations: 2
Eligibility criteria

Aged 13 to 15 years of age [+2]

Not in MOE registered school [+1]

Status: Recruiting

Psychiatric Outcomes of Unruptured Intracranial Aneurysms (POUIA)

The impact of cerebrovascular procedures on patients experiencing anxiety and depression is not well studied despite the high prevalence of these mental health disorders. Unruptured Intracranial aneurysms (UIAs) have a prevalence of approximately 3% and an annual risk of 1-2% in the general population. Despite the high risk of fatality following aneurysm rupture with a rate of 40-50%, the overall aneurysm growth and rupture risks are rare (less than 3% per aneurysm per year) and many patients can be observed with serial follow-up imaging over years. Nevertheless, due to the gravity of the bad consequences of aneurysm rupture, simply informing many patients of UIA diagnosis has been found to result in worse outcomes of health-related quality of life. This study aims to investigate the impact of awareness of untreated UIA on the patients' mental health utilizing the Hospital Anxiety and Depression Scale (HADS) tool.

Participants needed: 120
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Montefiore Medical CenterUpdated: Nov 19, 2025Locations: 1
Eligibility criteria

Unruptured intracranial aneurysms (UIA) [+5]

Prior history of Subarachnoid Hemorrhage (SAH) [+5]

Status: Recruiting

COVID-19 Health Adjustments in Nutrition, General Wellness, and Exercise

The purpose of this study is to find out whether the COVID pandemic has affected participants' current physical activity, fitness, blood pressure, sleep, and mental stress to better understand its long-term health effects. To complete this study, participants will visit the Neurovascular Physiology Laboratory (NVPL) at the Indiana University School of Public Health Bloomington two times, requiring a total commitment of about 6 hours. Visit 1 involves completing screening questionnaires, a consent document, and additional questionnaires about participant health behaviors (e.g., sleep and physical activity) and general mental and physical health. After the visit, participants will also start tracking their sleep and physical activity using wearable devices for 14 days, diet for at least 3 days, and blood pressure and urine for 24 hours. Visit 2 is a second data collection visit, where participants will return the wearable devices. The investigators will measure participants' body composition, take measures of their cardiovascular health, and participants will complete a fitness test on a stationary cycle (exercise bike). The investigators will collect a 24 hour urine sample and take a blood sample to measure participants' blood glucose, electrolytes, hydration biomarkers, and markers of inflammation, as well as to study immune cells. The investigators will take participants' blood pressure at rest and during a hand-in-cold water test, which helps assess how participants' nervous system responds to stress. A full-body scan will measure participant body composition including bone density, muscle mass, and body fat percentage. Finally, participants will complete a cycling test that gradually increases in intensity to measure cardiovascular fitness. Risks involve potential pain or bruising from blood draws, discomfort from blood pressure cuffs, stress from vigorous cycling, and psychological stress from questionnaires. There's also a slight risk of severe cardiovascular events occurring during exercise and loss of data confidentiality. Finally, the cold water test may result in a rare but noted situation where the body's nervous system overreacts to the cold stimulus, leading to a drop in blood pressure and heart rate. Participants will be monitored by trained staff during all procedures to ensure safety.

Participants needed: 100
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: Indiana UniversityUpdated: Oct 30, 2025Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Artificial Intelligence Powered Mental Health Support Tool For Physicians In Training

The purpose of this pilot study is to evaluate the acceptability of an artificial intelligence powered mental health support tool for mental health wellness amongst physicians in training. The primary research procedures are: The primary research procedure will be the utilization of artificial intelligence powered mental health support session through a web browser for physicians in training to address symptoms related to depression and anxiety. A pre and post intervention survey, evaluating depression symptoms with the standardized PHQ-9 questionnaire and anxiety symptoms with the standardized GAD-7 questionnaire will be conducted to assess changes in mental health wellness. The study will enroll physicians in training, including Internal Medicine residents and Gastroenterology fellows. The study includes at least 4 sessions. The total study duration for each subject is 3 months.

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Cedars-Sinai Medical CenterUpdated: Jul 25, 2025Locations: 1
Eligibility criteria

Individuals 18 years old or older are included. [+2]

Active treatment of severe and uncontrolled anxiety or depression with a health... [+2]

Status: Recruiting

Reducing Pregnancy Risks: The Mastery Lifestyle Intervention

This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 group sessions. The investigators will also have a usual care group that receives standard prenatal care. The investigators plan to enroll 238 pregnant women and start the study with them at 14-20 weeks gestation. The investigators will also test the biological response of the intervention by measuring Corticotropin Releasing Hormone, progesterone, estriol, and test for cotinine. The investigators will also determine any effect on infant outcomes at delivery.

Participants needed: 238
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Microgen LLCUpdated: Jul 17, 2025Locations: 1
Eligibility criteria

Providing informed consent; [+7]

Major systemic infections such as HIV, hepatitis [+10]

Status: Recruiting

Qoyangnuptu: Qoyangnuptu Intervention (QI) App

The goal of this clinical trial is to learn about the impacts of using a mobile health app, the Qoyangnuptu Intervention App (QI App) a Southwestern Tribal Community. The main questions it aims to answer are: In American Indian/Alaska Native communities with unique cultural characteristics, how should a youth-focused sociotechnical behavioral health intervention be designed to encourage sustained engagement and positively impact indicators of behavioral health?; How can interactive technical interventions be designed to best support sustained community engagement in a challenged network environment? Participants will: * Receive daily guidance and encouragement to use the app from an anonymous, trained peer mentor * Be able to ask their peer mentors questions in a monitored one-on-one chat in the QI app or in a monitored group chat in the QI app * Log their mood and stress level on the app once per day * Practice mindfulness skills as directed in the QI app, including guided breathing, meditation, drawing, coloring, and walking * Practice Hopi cultural activities like running using the QI app to help track progress towards team mileage goals

Participants needed: 24
Trial details
Age: 14-25Biological sex: AllType: InterventionalSponsor: Northern Arizona UniversityUpdated: Jan 23, 2025Locations: 1
Eligibility criteria

14-25 years old [+3]

Younger than 14 or older than 25 [+3]

Status: Recruiting

Qoyangnuptu: Peer Mentor

The goal of this clinical trial is to learn about the impacts of participating in a peer mentor program in a Southwestern Tribal Community. The main questions it aims to answer are: * In American Indian/Alaska Native communities with unique cultural characteristics, how should a youth-focused sociotechnical behavioral health intervention be designed to encourage sustained engagement and positively impact indicators of behavioral health?; * How can interactive technical interventions be designed to best support sustained community engagement in a challenged network environment? Participants will: * Be trained as peer mentors * Be trained in how to use the QI App to communicate with mentees * Guide daily conversation prompts with a group of 3 mentees via the QI App * Provide daily encouragement to mentees to engage with mindfulness activities on the QI App

Participants needed: 4
Trial details
Age: 18-30Biological sex: AllType: InterventionalSponsor: Northern Arizona UniversityUpdated: Jan 23, 2025Locations: 2
Eligibility criteria

Member of Southwestern Tribal Community [+2]

Has not completed GED/High School Diploma

Status: Recruiting

Effects of the 5 Ways to Wellbeing Course Effects of the 5 Ways to Wellbeing Course

Norway and other Western industrialized countries are facing major challenges in terms of preventable health problems, high work absence, largescale demographic changes and rising social inequalities in health. This project addresses the need for effective means to meet these important challenges. The project will scientifically evaluate The 5 Ways to Wellbeing course (5Ways), a novel measure aiming to promote wellbeing and integration, health and work adherence. Subjective wellbeing is systematically and prospectively related to important individual and societal outcomes, including social connectedness and integration, innovation, productivity, work performance, healthy behaviours, health and longevity. Promotion of wellbeing may therefore contribute to address the urgent societal ailments of today. Intervention effects and cost effectiveness of the 5Ways will be examined in-depth in four real-life settings, using quantitative methods. Specifically, we will investigate course impact wellbeing, health and work adherence among users of The Norwegian Labour and Welfare Administration (NAV) and clients in Healthy Life Centres. If effective, the course may be implemented nationwide and contribute to increase wellbeing and work participation. Findings from the study may thus contribute to enable municipalities and workplaces to make better priorities for promoting work presence, reducing suffering and improving mastery and quality of life among their inhabitants.

Participants needed: 700
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Norwegian Institute of Public HealthUpdated: Jan 16, 2025Locations: 1
Eligibility criteria

individuals with, or at high risk of disease, who need support in health behavio... [+1]

Severe mental illhealth [+1]

Status: Recruiting

Support Groups in the Metaverse for Ukrainian Refugees

The goal of this clinical trial is to test the efficacy of support groups held in the Metaverse, designed to promote mental health and well-being in Ukrainian refugees. Participants: * will be allocated to one of three conditions: (1) Metaverse support group (intervention); (2) In-Person support group (intervention); or (3) Waitlist. * will be asked to participate in 5 support group sessions, once per week, for each intervention condition. The Metaverse support groups will be compared with the In-Person support groups and with the Waitlist, to test: * the efficacy of the Metaverse condition compared to the In-Person condition. * the efficacy of the intervention conditions compared to the waitlist.

Participants needed: 45
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: University of BucharestUpdated: Dec 9, 2024Locations: 1
Eligibility criteria

Younger than 18. [+4]

Status: Recruiting

Internet Assisted Career-Oriented Soft-skills Training for Transition Age Youth with Mental Health Conditions

The purpose of this study is to evaluate the effectiveness of an internet- assisted Career-Oriented Work-Related Soft-skills Training (iCareer) intervention, infused with cognitive behavioral therapy, targeting individuals ages 16-24 with mental health conditions, to improve employment outcomes. The overall objective is to help transition-age youth (TAY) with psychiatric disabilities achieve optimal employment outcomes as part of successful transition to adulthood. Findings will have implications for enhancing and developing pre-employment services for TAY with psychiatric disabilities.

Participants needed: 126
Trial details
Age: 16-24Biological sex: AllType: InterventionalSponsor: Rutgers, The State University of New JerseyUpdated: Nov 14, 2024Locations: 1
Eligibility criteria

Age between 16 and 24 years [+5]

Current presence of neurological disease or brain injury [+3]

Status: Recruiting

Healthy Early Life Moments in Singapore

This study aims to assess whether an integrated continuum of care from the preconception period, across maternity until the first 18 months of life, can promote maternal metabolic and mental health, as well as offspring health, among overweight and obese women.

Participants needed: 500
Trial details
Age: 21-40Biological sex: FemaleType: InterventionalSponsor: KK Women's and Children's HospitalUpdated: Oct 10, 2024Locations: 1
Eligibility criteria

Women aged 21-40 years [+6]

Currently pregnant [+6]

Status: Not yet recruiting

The Effect of Multi-Strategy Approaches on Limiting Digital Exposure

In the digital age, university students are increasingly immersed in a technology-driven environment where smartphones, social media, and various digital platforms play a central role in their daily lives. While these technologies offer significant benefits, such as enhanced connectivity, access to information, and educational resources, they also pose potential risks to mental health. Excessive screen time, constant connectivity, and the pressure to maintain an online presence can lead to negative outcomes, including anxiety, depression, sleep disturbances, and reduced academic performance.

Participants needed: 700
Trial details
Age: 18-25Biological sex: AllType: InterventionalSponsor: Universiti Putra MalaysiaUpdated: Aug 28, 2024
Eligibility criteria

Participants must be enrolled as students at any of the three universities of La... [+5]

Individuals who have been diagnosed with severe psychiatric disorders (such as s... [+2]

Status: Recruiting

Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes

By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas. The overarching purpose of the proposed project is to: i. increase physical activity levels among school-aged children, independent of socioeconomic factors, and thus affect short- and long-term health outcomes on a population level ii. establish an evidence-based bottom-up approach for schoolyard reconstructions iii. evaluate the cost-effectiveness of schoolyard reconstructions with greening on health outcomes and its environmental impact

Participants needed: 3,600
Trial details
Age: 8-13Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Jun 20, 2024Locations: 1
Eligibility criteria

Enrolled in participating school [+3]

Not enrolled in participating school [+2]

Status: Recruiting

Mental Health Literacy and Academic Performance

The goal of this clinical trial is to test the effectiveness of an intervention designed to promote mental health literacy in adolescents. The main questions it aims to answer are: 1. Whether this intervention can have an impact on mental health 2. Whether this intervention can have an impact on fostering academic performance, particularly in disadvantaged students (i.e., academic resilience) 3. Whether this intervention will have differential effectiveness as a function of the delivery format (psychoeducational materials only versus blended) Participants will receive either an online, automated intervention consisting of psychoeducational materials delivered at predetermined intervals (automated), or the same but with the addition of synchronous or asynchronous psychoeducational sessions held by a licensed psychologist (i.e., blended). These two conditions will also be compared to a Waitlist, to test if the interventions perform better than no treatment.

Participants needed: 264
Trial details
Age: 14-18Biological sex: AllType: InterventionalSponsor: University of BucharestUpdated: Jun 18, 2024Locations: 1
Eligibility criteria

Enrolled in High School

Younger than 14 or older than 18

Status: Not yet recruiting

Evaluating the Hope@School Prevention Program

This multi-center cluster-randomized controlled trial aims to evaluate the feasibility, effectiveness and overall impact of the Hope@School (H@S) program by comparing mental health outcomes in students participating in the H@S program with students having only access to regular student health care (treatment as usual - TAU). The primary objectives of the study are: To determine if the H@S program is feasible, acceptable, usable and safe for students, families, teachers and school leaders To establish if the H@S program is associated with improvements in quality of life, everyday functioning, peer relations and general mental health.

Participants needed: 3,220
Trial details
Age: 8-18Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Apr 11, 2024
Eligibility criteria

Age between 8 and 18 years [+2]

Status: Recruiting

Effects of a Relaxation and Guided Imagery Intervention in School Context

Specific aims - To test the effects of a relaxation and guided imagery intervention with socioemotional learning content on a range of socioemotional, physiological, cognitive and academic outcomes of school-aged children, measured through self-reports, neuropsychological and physiological measures, as well as teachers and parent's reports.

Participants needed: 240
Trial details
Age: 7-12Biological sex: AllType: InterventionalSponsor: Universidade Autónoma de LisboaUpdated: Nov 7, 2023Locations: 1
Eligibility criteria

Attend the 3rd and 4th grade of the selected school (8-11 years-old)

The participant classes have benefited from the RegularMind intervention previou... [+1]

Status: Recruiting

Fathers and Partners in Family Integrated Care Study

AIMS: The primary aim is to investigate the impact of enhancing father/partner engagement in FICare of preterm infants on their mental health (MH) up to 6 weeks post discharge. Secondary aims are to investigate the impact on maternal MH. METHOD and ANALYSIS: This is a two-phase study: Phase-1 to gather baseline information and Phase-2 to assess the impact of improved father/partner engagement in FICare involving two NUs (a tertiary and level 2). 20 families of infants born at \<33 weeks will be studied in each phase (40 fathers, 40 mothers, 40 babies). Father/partner MH will be assessed using validated questionnaires: Generalised Anxiety Disorder Assessment (GAD-7), Patient Health Questionnaire (PHQ-9), Parental Stressor Scale: NICU (PSS:NICU), and by semi-structured qualitative interviews. Similarly, mothers will be assessed by the same questionnaires and focus groups. The Neonatal DadPad materials will be updated using information from phase 1 study, systematic review of Fathers experiences of FICare and advice from parent advisory group. Father's engagement in FICare will be enhanced using Neonatal DadPad information booklet and app, father-specific peer support and bitesize teaching on caring for NU babies (Phase 2). Thematic analysis of the qualitative data will be performed. Phase 1 and Phase 2 study findings will be compared by performing appropriate statistical analysis.

Participants needed: 40
Trial details
Biological sex: AllType: ObservationalSponsor: Homerton University Hospital NHS Foundation TrustUpdated: Sep 5, 2023Locations: 2
Eligibility criteria

Parents of 22+0 to 32+6 weeks preterm infants. [+3]

Infant with life-limiting condition or no realistic chance of survival. [+2]

Status: Not yet recruiting

Promoting a Healthy Life Through Gender Equity

Mental health, understood as the individual or group well-being at an emotional, psychological, and/or social level, affects up to 35% of university students, of whom only 16.4% seek or receive help from healthcare professionals. Despite this prevalence and its impact on academic performance and the challenges faced by universities in terms of limited resources to address this situation, most research tends to focus on primary and/or secondary education stages. Consequently, there is limited research on the reasons why university students experience mental health problems and why they do not seek help. Physical activity and reducing sedentary behaviour could be protective factors for mental health in both children and adolescents. In this regard, according to data from the DESK-Uni at UVic-UCC, university students report engaging in low levels of physical activity, with female students reporting lower levels than male students. Additionally, adolescent girls report more mental health problems than boys. Therefore, there is a need for research and projects that consider the gender bias in health that exists in our society, including universities. This bias could explain why girls engage in less physical activity or claim to do so and why they experience more mental health problems. Thus, the purpose of the project is to improve or reduce gender inequalities within the university community and their impact on health behaviour (physical activity/sedentary behaviour) and mental health of both students and staff members. Overall, the project aims to decrease the risks of experiencing mental health problems in the university environment by enhancing identification and promoting health-related behaviours that act as protective factors (e.g., physical activity). This will be done by considering the intersectionality of inequality axes present in our society and reproduced within the university setting. To do it, the Sustainable Development Goals (SDG; 3-4-5) will be taken in consideration.

Participants needed: 350
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Fundació Universitària del BagesUpdated: Jul 27, 2023Locations: 1
Eligibility criteria

Individuals involved in the university community, including students and staff m... [+1]

Lack of a B2 proficiency level in either Catalan or Spanish language (as determi... [+1]